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The diet is a major factor affecting the Body Mass Index (BMI) of an individual. BMI has long been the standard for measuring health and its normal range (18.5-24.9, according to the World Health Organization) is considered to be crucial for maintenance of proper health and to prevent various lifestyle disorders which are considered to have either direct or indirect effects on physical and mental well-being of our youth. To investigate the correlation between diet patterns and BMI, overall stamina and fatigue levels in the youth population residing in Delhi-NCR region of India. An online survey was conducted using a carefully designed Google form and the respondents were asked to give details about the basic health parameters and dietary lifestyle. 67% of the respondents who consumed milk were found to have an ideal BMI. 64% of the respondents who consumed mustard oil as their predominant dietary fat showed normal BMI and more than 80% showed lower fatigue levels. Milk and mustard oil consumption is important for maintenance of an ideal BMI. Awareness should be created in the youth to have them as part of their daily diet.
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http://dx.doi.org/10.1177/02601060221116198 | DOI Listing |
J Nepal Health Res Counc
June 2025
harmacy Program, Gandaki University, Gyankunja, Pokhara, Kaski, Nepal, Research Center, Invention and Innovation Center, Gandaki University, Pokhara, Kaski, Nepal.
Background: Vector borne diseases are one of the prevailing global healthcare problems caused by mosquito bites. The main objective of this study was to determine the strategies used for the prevention of mosquito bites by general public of Kaski district, a mosquito bite prone area of Western Nepal, as evidenced by rising dengue cases.
Methods: A cross-sectional study with 435 households were surveyed, for the strategies used for mosquito bite prevention, in representative 15 wards of one metropolitan and four rural municipalities of Kaski district, selected by simple random sampling technique.
Br J Pharmacol
August 2025
Department of Dermatology, Venereology and Oncodermatology, University of Pécs Medical School, Pécs, Hungary.
Background And Purpose: Psoriasis is a chronic, relapsing, immune-mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. Here, we investigated the pharmacological activation and blockade of TRPA1 in human skin (patho)physiology.
View Article and Find Full Text PDFFASEB J
July 2025
Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Crucial to homeostasis, vascular barrier function depends upon coordinated interplay between endothelial (ECs) and mural cells, including vascular smooth muscle cells (vSMCs) and pericytes, that stabilize the vasculature. Kindlin-2 (K2) is an integrin co-activator regulating various cellular responses, but its role in mural cell-dependent vascular stabilization is unknown. The role of K2 in mural cell-mediated regulation of vascular barrier function was investigated.
View Article and Find Full Text PDFJ Lipid Res
July 2025
Department of Pharmacology and Pharmacotherapy & Centre for Neuroscience, Faculty of Medicine, University of Pécs, Pécs, Hungary; National Laboratory for Drug Research and Development, Budapest, Hungary; Hungarian Research Network, Chronic Pain Research Group, University of Pécs (HUN-REN PTE), P
The nociceptive Transient Receptor Potential Vanilloid 1 (TRPV1) and Ankyrin 1 (TRPA1) channels are predominantly expressed on peptidergic sensory nerves, being involved in pain sensation and neurogenic inflammation induced by local release of pro-inflammatory neuropeptides in the innervation area. Their activation is facilitated by cholesterol-rich lipid microdomains (lipid rafts) in the plasma membrane. Cyclodextrin (CD) derivatives deplete cholesterol from membrane rafts, reducing receptor activation in vitro, anticipating in vivo analgesic effects.
View Article and Find Full Text PDFNeurotoxicology
May 2025
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Electronic address:
Zebrafish (Danio rerio) behavioral assays provide valuable insights into the effects of environmental chemicals on the developing nervous system, primarily through motor responses triggered by stimuli-induced CNS activation. However, as these responses rely on the locomotor integrity of larval zebrafish, chemical-induced impairments to their locomotor capacity could obscure behavioral observations and confound findings concerning the developmental neurotoxicity of the tested chemicals. This limitation emphasizes the need for supporting assays designed to specifically evaluate the locomotor capacity of larval zebrafish.
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