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We report a rare case of ectopic breast tissue situated in a unique location. A 50-year-old female patient came to our institution complaining of a bulge in the inguinal area. CT was unremarkable other than a benign-looking conglomeration of lymph nodes around the inguinal canal. However, excisional biopsy proved otherwise, with strong expression of breast-related immunohistochemical markers on pathology. Based on histological findings, the diagnosis of ectopic breast tissue was made. Since the vast majority of ectopic breast tissue is found around the breast mound, axilla, and along the milk line, this case is peculiar in its location. This report shares our experience and provides indications for excision of incidental ectopic breast tissue.
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http://dx.doi.org/10.3389/fsurg.2022.894416 | DOI Listing |
Cancer Lett
September 2025
Departments of Interdisciplinary Oncology and Genetics, Stanley S. Scott Cancer Center, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. Electronic address:
Basal-like breast cancer (BLBC) is a major subtype of triple-negative breast cancer (TNBC), characterized by aggressive behavior, limited treatment options, and poor prognosis. While HER3 overexpression is frequently observed in TNBC and associated with poor outcomes, its subtype-specific expression and therapeutic potential remain unclear. Here, we demonstrated that HER3 signaling is selectively hyperactivated in BLBC compared to claudin-low breast cancer (CLBC) using transcriptomic profiling.
View Article and Find Full Text PDFSci Adv
September 2025
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.
Breast cancer is hallmarked by phenotypic transitions enabling abnormal cell proliferation and invasion. The stress-protective transcription factor heat shock factor 2 (HSF2) is associated with cancer, but its function in breast carcinogenesis remains poorly understood. Analysis of human breast tumor samples and mouse in vivo xenografts uncovered that HSF2 expression and activity undergo dynamic changes as a function of tumor progression.
View Article and Find Full Text PDFCureus
July 2025
Center for Breast Care, Hospital Angeles Valle Oriente, San Pedro Garza Garcia, MEX.
Ectopic breast tissue (EBT) is an uncommon congenital condition resulting from incomplete involution of the milk line. Primary carcinomas arising in EBT have been reported in a small number of cases, most frequently in the axilla, but they may occur anywhere along the mammary line. Here, we present the case of a 69-year-old woman who presented with an asymptomatic subcutaneous nodule located at the end of a Pfanneistein's laparotomy scar in the suprapubic region.
View Article and Find Full Text PDFJ Surg Case Rep
August 2025
Department of Surgery, Breast, Endocrine and Laparoscopic Surgery, King Abdullah Bin Abdulaziz University Hospital Princess Norah university, Airport Road, King Khalid International Airport, Riyadh 11564, Riyadh Province, Saudi Arabia.
There have been reports of gallbladders in several ectopic locations. A gallbladder that is intrahepatic is one that is located along the anterior inferior right lobe of the liver or within the liver parenchyma. A 39-year-old male patient presented with symptoms that led to a gallbladder origin and was worked up using ultrasonography, which confirmed the presence of a contracted gallbladder with multiple stones.
View Article and Find Full Text PDFIdentifying drivers of metastasis is essential for developing new treatments for patients with advanced disease. Here, we identify as a robust driver of breast cancer metastasis. Previous work established as an imprinted gene expressed by trophoblasts which are critical for vascular remodeling during placental development.
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