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Background: In terms of public health, vaccination is considered as the most effective approach against the infectious diseases. Accepting and receiving the first vaccine produced as an innovation may not be easy. Therefore, the present study was conducted to investigate the predictors of intention to receive COVID-19 vaccine by Iranians aged 18-70 years based on the health belief model in 2021.
Materials And Methods: This descriptive study was performed on 2365 people aged 18-70-year old in Iran by random cluster sampling. Receipt of data was done electronically questionnaire through the Porcelain system. Data were analyzed using SPSS software version 20 using Chi-square, one-way analysis of variance, independent -test, and multiple regression analysis at a significance level of 0.05.
Results: The mean score of receiving the Iranian corona vaccine was 3.06 ± 1.30 out of 5 points. About 16.7% reported that they will definitely choose the Iranian vaccine. The highest correlation was between the intention to receive the vaccine with self-efficacy ( = 0.239, < 0.001) and barriers to receiving the vaccine ( = -0.237, < 0.001). Self-efficacy (β = 0.114, < 0.001), perceived barriers (β = -0.126, < 0.001), and benefits of vaccine (β = 0.061, = 0.022) were most important predictors the intention to receive the vaccine.
Conclusion: Approximately 38% reported that they would definitely and probably not choose the Iranian corona vaccine. Therefore, it is suggested that more information should be provided about the features and benefits of domestically produced vaccines compared to foreign products.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9277725 | PMC |
http://dx.doi.org/10.4103/jehp.jehp_647_21 | DOI Listing |
J Am Coll Cardiol
September 2025
Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong Special Administrative Region of China; Advanced Data Analytics for Medical Science Limited, Hong Kong Special Administrative Region of China
Background: There is no consensus for using statins for primary prevention of cardiovascular disease (CVD) and all-cause mortality in adults with type 1 diabetes mellitus (T1DM), because no randomized controlled trial has exclusively investigated statins in this population.
Objectives: In this study, the authors sought to evaluate the long-term risks and benefits of statins for primary prevention in adults with T1DM.
Methods: We performed a sequential target trial emulation comparing statin initiation vs noninitiation using UK primary care data from the IQVIA Medical Research Data database.
BMJ Open
September 2025
Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxication, University Hospital Heidelberg, Heidelberg, Germany.
Introduction: Combined vascular endothelial growth factor/programmed death-ligand 1 blockade through atezolizumab/bevacizumab (A/B) is the current standard of care in advanced hepatocellular carcinoma (HCC). A/B substantially improved objective response rates compared with tyrosine kinase inhibitor sorafenib; however, a majority of patients will still not respond to A/B. Strong scientific rationale and emerging clinical data suggest that faecal microbiota transfer (FMT) may improve antitumour immune response on PD-(L)1 blockade.
View Article and Find Full Text PDFChest
September 2025
Child and Maternal Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia; School of Nursing and Midwifery, Charles Darwin University, Darwin, Northern Territory, Australia.
Background: Managing bronchiectasis exacerbations is a priority for patients/parents/caregivers of children with bronchiectasis, yet evidence-based strategies among the pediatric population remain limited.
Research Question: Does the use of a personalized, written bronchiectasis action management plan (BAMP), compared to standard care, reduce non-scheduled doctor visits among children/adolescents with chronic suppurative lung disease (CSLD)/bronchiectasis?
Study Design And Methods: Our multicenter, double-blind, superiority, randomized controlled trial enrolled children from three Australian respiratory departments between June 2018 and December 2020. Children/adolescents aged <19 years with CSLD/bronchiectasis were randomized to receive a personalized BAMP (intervention) or standard care (controls).
Vaccine
September 2025
Institute of General Practice and Family Medicine, LMU University Hospital, LMU, Munich, Germany; German Center of Mental Health, Augsburg, Munich, Germany.
Background: Chronically ill are advised to receive annual vaccinations against Covid-19 and seasonal influenza. Furthermore, chronically ill show an increased prevalence of comorbid common mental disorders (CMDs), like depression, anxiety, and somatoform disorders. With vaccination rates remaining insufficient among these vulnerable patients, prior research assumes an association between CMDs and vaccination readiness.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
National Institute of Public Health, University of Southern Denmark, Copenhagen K, Denmark.
Background: The high and increasing rate of poor mental health among young people is a matter of global concern. Experiencing poor mental health during this formative stage of life can adversely impact interpersonal relationships, academic and professional performance, and future health and well-being if not addressed early. However, only a few of those in need seek help.
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