Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Enteropathy-associated T-cell lymphoma (EATL) is a rare but serious complication of celiac disease. Diagnosis is challenging. Patients can present with weight loss, abdominal pain, and diarrhea or acutely with bowel perforation or obstruction. Patients often present with advanced disease. Malnutrition further limits treatment options. Early diagnosis is important to start aggressive treatment strategies. However, even with prompt diagnosis, prognosis remains poor with a high mortality rate. We report the first documented case of sole tonsillar involvement, a rare extraintestinal and extranodal site of disease, leading to EATL diagnosis. We also highlight some of the challenges in diagnosing EATL.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9263477PMC
http://dx.doi.org/10.14309/crj.0000000000000824DOI Listing

Publication Analysis

Top Keywords

enteropathy-associated t-cell
8
t-cell lymphoma
8
celiac disease
8
tonsillar extraintestinal
4
extraintestinal enteropathy-associated
4
lymphoma patient
4
patient celiac
4
disease
4
disease enteropathy-associated
4
lymphoma eatl
4

Similar Publications

(1) Background: Monomorphic intestinal epitheliotropic T-cell lymphoma (MEITL) is a very rare subtype of lymphoma, being involved in less than 5% of lymphomas of the digestive tract. Accurate diagnosis is extremely challenging due to the lack of specific clinical symptoms and the low specificity of the diagnostic approaches. (2) Methods: We present the case of a patient admitted to the Neurology Clinic of the Emergency Clinical Hospital of Galati, Romania, with progressive cranial nerve impairment.

View Article and Find Full Text PDF

Human enteropathy-associated T-cell lymphoma (EATL) is a rare primary aggressive intestinal T-cell lymphoma associated with celiac disease and is considered to be a neoplasm of intraepithelial lymphocytes (IELs) with an innate lymphoid cell (ILC)-like immunophenotype. The lack of an animal model has delayed the elucidation of its pathogenesis. In dogs, the histopathological and immunophenotypic features of intestinal large T-cell lymphoma (ILTCL) are similar to EATL; however, its cell of origin remains unclear.

View Article and Find Full Text PDF

The goal of this prospective, single-arm pilot study was to assess tolerability and clinical benefit for cats with histologically confirmed lymphocytic lymphoma/chronic inflammatory enteropathy complex (FLL/CIE) treated with low-dose abdominal cavity radiation therapy (RT; 8 Gy total dose administered in four 2 Gy fractions). No cats received steroids or chemotherapy prior to RT. Fourteen cats were enrolled and 13 completed the study.

View Article and Find Full Text PDF

Peripheral T-cell lymphomas (PTCLs) represent a heterogeneous group of rare malignancies with poor survival; however, population-based long-term survival data remain limited. We conducted a nationwide study to estimate overall survival (OS) and relative survival (RS) among 915 patients diagnosed with PTCLs from 2002 - 2018 (57% males, median age 67 years) using the Finnish Cancer Registry. The most common subtypes included PTCL not otherwise specified (PTCL NOS; 37%), angioimmunoblastic T-cell lymphoma (AITL; 27%), and ALK-anaplastic large cell lymphoma (ALK-ALCL; 12%).

View Article and Find Full Text PDF

Objectives: To review and discuss cases submitted to the 2023 Society of Hematopathology/European Association for Haematopathology workshop session entitled "Non-cutaneous Cytotoxic T-cell Lymphomas Including Hepatosplenic T-cell Lymphoma and Intestinal T-cell Lymphomas.

Methods: A total of 45 cases were submitted by various contributors. These cases included clinicopathologic, immunophenotypic and molecular data.

View Article and Find Full Text PDF