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http://dx.doi.org/10.1016/j.oraloncology.2022.106010 | DOI Listing |
World J Surg Oncol
September 2025
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No.1 Shuaifuyuan Dongcheng District, Beijing, 100730, China.
Purpose: We reviewed recent advancements in the characterization of intraductal oncocytic papillary neoplasm (IOPN) of the pancreas, with a specific focus on developments in immunohistochemical markers, molecular pathology, and pathogenic mechanisms over the past ten years (2015-2024). Through comprehensive analysis of current literature, we aimed to elucidate the evolving understanding of IOPN's biological behavior and diagnostic features, while identifying potential areas for future research in this distinctive pancreatic neoplasm.
Methods: English-language articles on IOPN were searched from Pubmed from the first report of IOPN of the pancreas in 2015 to 2024.
J Urol
September 2025
Department of Urology, Austin Health, Melbourne, Victoria, Australia.
Purpose: Prostate-specific membrane antigen positron emission tomography (PSMA PET) is increasingly used to diagnose and stage prostate cancer. A PRIMARY score uses anatomical localization and uptake patterns to improve diagnostic accuracy. We evaluated the histopathology of patients with no uptake pattern (PRIMARY score 1) and the prevalence of intraductal carcinoma of the prostate (IDC-P) in this subset compared with those with an uptake pattern (PRIMARY score ≥ 2).
View Article and Find Full Text PDFInt Urol Nephrol
September 2025
Brody School of Medicine (BSOM), East Carolina University (ECU), 600 Moye Blvd, Greenville, NC, 27834, USA.
Sci Adv
September 2025
Faculty of Science and Engineering, Cell Biology, Åbo Akademi University, Turku, Finland.
Breast cancer is hallmarked by phenotypic transitions enabling abnormal cell proliferation and invasion. The stress-protective transcription factor heat shock factor 2 (HSF2) is associated with cancer, but its function in breast carcinogenesis remains poorly understood. Analysis of human breast tumor samples and mouse in vivo xenografts uncovered that HSF2 expression and activity undergo dynamic changes as a function of tumor progression.
View Article and Find Full Text PDFBreast Cancer
September 2025
Division of Surgical Oncology, Department of Surgery, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
Background: Morphological features of tumors can reflect the biological behavior of breast carcinoma; however, a consensus macroscopic classification remains elusive. In this study, we aimed to elucidate the relationship between macroscopic morphology and biological behavior of breast carcinoma.
Methods: We evaluated 328 post-operative breast carcinomas, stratifying them by hormone receptor/human epidermal growth factor receptor 2 (HER2) status (luminal-like, luminal-HER2, HER2-positive [non-luminal], triple-negative), and morphological patterns.