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An 11-month-old male infant with ascending paralysis had an unremarkable initial cerebrospinal fluid (CSF) analysis and imaging. Progressive neurological symptoms resulted in repeated CSF sampling, microscopy, and plasma microbial cell-free DNA next-generation sequencing analysis, that in combination with epidemiology, confirmed the diagnosis.
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http://dx.doi.org/10.1093/jpids/piac048 | DOI Listing |
Int J Emerg Med
September 2025
Department of Anesthesia, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Background: Growing evidence suggests a close association between circulating micronutrient levels and neuroimmune diseases. Nevertheless, the causal relationship between them remains unclear. Furthermore, due to confounding factors, many micronutrients implicated in these diseases remain unidentified.
View Article and Find Full Text PDFLupus Sci Med
September 2025
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background: SLE has increased risk of invasive pneumococcal disease due to immune dysregulation and immunosuppression. European Alliance of Associations for Rheumatology recommendations suggest sequential vaccination with conjugate vaccine, followed by 23-valent pneumococcal polysaccharide vaccine (PPSV23). However, data on immunogenicity of sequential vaccination in SLE are limited.
View Article and Find Full Text PDFCurr Opin Neurol
October 2025
Neuromuscular Diseases Unit, Department of Neurology, IR SANT PAU, Hospital de la Santa Creu i Sant Pau, CIBERER, Barcelona, Spain.
Purpose Of Review: Autoimmune nodopathies (AN) are a recognized distinct group of immune-mediated peripheral neuropathies with unique immunopathological features and therapeutic implications. This review synthesizes recent advances in their pathogenesis, diagnosis, and management, which have refined their clinical classification and informed targeted treatment strategies.
Recent Findings: AN are characterized by autoantibodies targeting surface proteins in the nodal-paranodal area (anti-contactin-1, anti-contactin-associated protein 1, anti-neurofascin-155, anti-pan-neurofascin), predominantly of IgG4 subclass.
Mil Med
September 2025
Soldier Centered Medical Home-CAB, Desmond Doss Health Clinic, Wahiawa, Hawaii, HI 96786, United States.
Guillain-Barré Syndrome (GBS) is an acute immune-mediated inflammatory demyelinating polyradiculopathy of the peripheral nerves often provoked by a preceding upper respiratory or gastrointestinal infection. Guillain-Barré Syndrome usually presents with symmetrical lower limb ascending weakness and decreased deep tendon reflexes. Here, we describe a case of an uncommon presentation of GBS presenting with upper extremity neuropathy and cranial nerve palsy in a 36-year-old Caucasian Army pilot.
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