Clinical Benefits of Golden- Containing Antroquinonol in Liver Protection and Liver Fat Reduction After Alcoholic Hepatitis.

It has been reported that antroquinonol extracted from Golden- exerts protective effects on liver function both . However, the protective effects of Golden- on liver function have not been fully investigated in human clinical studies. Therefore, the present study aimed to evaluate the beneficial effects of Golden- on hepatic function after alcohol consumption in human subjects. A total of 80 participants with increased γ-glutamyl transferase levels (60-180 U/L) were enrolled in the current study and were randomly divided into two groups. Participants in the first group were orally administrated with 300 mg/day Golden- (tablets), while those in the second group received placebo tablets for 12 weeks. Biochemical routine blood tests were performed at 6 and 12 weeks following the first administration. At 12 weeks post the first Golden- administration, the serum levels of aspartate aminotransferase (AST; < 0.0001), alanine aminotransferase (ALT; = 0.0002) and triglyceride ( = 0.0158) were notably declined in the Golden- treatment group compared with the placebo group. No clinically significant differences were observed between the Golden- treatment and placebo groups in terms of general safety parameters. A statistically significant difference was obtained in the serum levels of AST, ALT and triglycerides between the Golden- and placebo groups. However, no clinical significance was observed in any of the safety parameters examined. Overall, these findings indicated that treatment with Golden- exerted protective effects on liver function.