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Exponential-family Random Graph models (ERGM) are widely used in social network analysis when modelling data on the relations between actors. ERGMs are typically interpreted as a snapshot of a network at a given point in time or in a final state. The recently proposed Latent Order Logistic model (LOLOG) directly allows for a latent network formation process. We assess the real-world performance of these models when applied to typical networks modelled by researchers. Specifically, we model data from an ensemble of articles in the journal with published ERGM fits, and compare the ERGM fit to a comparable LOLOG fit. We demonstrate that the LOLOG models are, in general, in qualitative agreement with the ERGM models, and provide at least as good a model fit. In addition they are typically faster and easier to fit to data, without the tendency for degeneracy that plagues ERGMs. Our results support the general use of LOLOG models in circumstances where ERGMs are considered.
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http://dx.doi.org/10.1111/rssa.12788 | DOI Listing |
J Alzheimers Dis
September 2025
Paula Costa-Urrutia Medical Affairs, Terumo BCT, Edificio Think MVD, Montevideo, Uruguay.
BackgroundTherapeutic plasma exchange (TPE) with albumin replacement has emerged as a potential treatment for Alzheimer's disease (AD). The AMBAR trial showed that TPE could slow cognitive and functional decline, along with changes in core and inflammatory biomarkers in cerebrospinal fluid.ObjectiveTo evaluate the safety and effectiveness of TPE in a real-world setting in Argentina.
View Article and Find Full Text PDFJAMA Dermatol
September 2025
Department of Dermatology, University of Washington, Seattle.
Importance: Merkel cell carcinoma (MCC) is typically caused by the Merkel cell polyomavirus (MCPyV) and recurs in 40% of patients. Half of patients with MCC produce antibodies to MCPyV oncoproteins, the titers of which rise with disease recurrence and fall after successful treatment.
Objective: To assess the utility of MCPyV oncoprotein antibodies for early detection of first recurrence of MCC in a real-world clinical setting.
Mol Biol Rep
September 2025
School of Arts and Sciences, Department of Natural and Applied Sciences, The American University of Iraq-Baghdad, Baghdad, Iraq.
The COVID-19 pandemic, caused by the continuously evolving SARS-CoV-2 virus, has presented persistent global health challenges. As novel variants emerge, many with enhanced transmissibility and immune evasion capabilities, concerns have intensified regarding the efficacy of existing vaccines and therapeutics. This review provides a comprehensive overview of the current landscape of COVID-19 vaccination, including the development and performance of monovalent and bivalent boosters, and examines their effectiveness against newly emerging variants of interest (VOIs) and variants under monitoring (VUMs), such as JN.
View Article and Find Full Text PDFChaos
September 2025
School of Computational Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Although many real-world time series are complex, developing methods that can learn from their behavior effectively enough to enable reliable forecasting remains challenging. Recently, several machine-learning approaches have shown promise in addressing this problem. In particular, the echo state network (ESN) architecture, a type of recurrent neural network where neurons are randomly connected and only the read-out layer is trained, has been proposed as suitable for many-step-ahead forecasting tasks.
View Article and Find Full Text PDFBiomed Environ Sci
August 2025
Precision Key Laboratory of Public Health, School of Public Health, Guangdong Medical University, Dongguan 523808, Guangdong, China;Maternal and Child Research Institute, Shunde Women and Children's Hospital, Guangdong Medical University, Foshan 528300, Guangdong, China.
Objective: Humans are exposed to complex mixtures of environmental chemicals and other factors that can affect their health. Analysis of these mixture exposures presents several key challenges for environmental epidemiology and risk assessment, including high dimensionality, correlated exposure, and subtle individual effects.
Methods: We proposed a novel statistical approach, the generalized functional linear model (GFLM), to analyze the health effects of exposure mixtures.