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http://dx.doi.org/10.1016/j.jpeds.2022.05.050 | DOI Listing |
BMC Infect Dis
September 2025
Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No.20, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, P.R. China.
Background: Early-onset neonatal sepsis (EOS) is a critical condition primarily caused by maternal-fetal transmission of bacterial pathogens during delivery, with Escherichia coli and Group B Streptococcus being the most prevalent. However, neonatal sepsis can also involve other rare bacteria, including Corynebacterium amycolatum, which was first described in 1988 and is widely recognized as an emerging pathogen in infectious diseases.
Case Presentation: A male infant was admitted to the neonatal intensive care unit (NICU) due to premature birth and tachypnea.
Ann Clin Microbiol Antimicrob
August 2025
Breastfeeding Research Center, Family Health Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Background: Neonatal sepsis is a major cause of morbidity and mortality worldwide. The COVID-19 pandemic has influenced its epidemiology, altering pathogen distribution and antimicrobial resistance patterns, necessitating a reassessment of neonatal infection management. This study aims to evaluate the impact of the COVID-19 pandemic on neonatal sepsis incidence, pathogen distribution, and antimicrobial resistance patterns, providing evidence to inform improved clinical management strategies in neonatal intensive care units.
View Article and Find Full Text PDFJ Med Case Rep
August 2025
Department of Pediatrics, Dil-Fana Hospital, Arba Minch, Ethiopia.
Background: Malaria remains a significant public health concern, particularly in Africa, where children under 5 years of age are affected. While mosquito bites are the primary transmission route, congenital malaria caused by transplacental or perinatal transmission can also occur. This case report highlights the challenges in diagnosing congenital malaria and emphasizes the importance of considering it in neonates, especially those born in or with a travel history to endemic areas.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
August 2025
Division of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung, Taiwan.
Background: Neonatal sepsis remains a significant cause of morbidity and mortality among newborns worldwide. Although the implementation of intrapartum antibiotic prophylaxis (IAP) has led to changes in the microbiological landscape of early-onset sepsis (EOS), the incidence among full-term neonates has not declined as expected. This underscores the ongoing need to identify and understand maternal and neonatal risk factors to inform more effective prevention strategies.
View Article and Find Full Text PDFInfect Immun
August 2025
Department of Medicine, Division of Infectious Diseases, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Vaginal colonization by also known as Group B (GBS), is a major risk factor for ascending infections, preterm birth, and neonatal sepsis. Current GBS prevention efforts include routine GBS perinatal screening and intrapartum antibiotic prophylaxis, which decrease the rate of early-onset neonatal sepsis, but have drawbacks that include impacting the infant's developing microbiome. -dominant vaginal microbiomes provide protection against pathogens such as GBS, and using probiotics as an antibiotic-free approach to limit GBS colonization is of increasing interest.
View Article and Find Full Text PDF