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http://dx.doi.org/10.34067/KID.0006112021 | DOI Listing |
Diabetes Metab Syndr Obes
September 2025
Department of Nephrology, Wuyi County First People's Hospital, Jinhua City, Zhejiang Province, People's Republic of China.
Purpose: Metabolic syndrome (MetS) is linked to adverse outcomes in chronic diseases, but its impact on acute kidney injury (AKI) in elderly critically ill patients remains unclear. This study aimed to evaluate the association between MetS and 90-day mortality in this population.
Patients And Methods: A retrospective analysis included 774 elderly patients (≥65 years) with AKI admitted to the ICU from January 2022 to December 2023.
Front Nephrol
August 2025
Department of Nephrology, Instituto Português de Oncologia do Porto Francisco Gentil, Porto, Portugal.
Background: High-dose methotrexate (HDMTX) is central to treating primary central nervous system lymphoma but carries a risk of acute kidney injury (AKI), which can delay methotrexate (MTX) clearance and increase toxicity. Glucarpidase is the treatment of choice for MTX toxicity, but limited access in many countries may necessitate alternatives. We present the first reported adult case of combined high-flux hemodialysis (HFHD) and HA230 hemoadsorption for MTX clearance.
View Article and Find Full Text PDFCureus
August 2025
Internal Medicine, Bharati Vidyapeeth (Deemed to be University) Medical College and Hospital, Pune, IND.
Drug-induced immune hemolytic anemia (DIIHA) is a rare secondary cause of autoimmune hemolytic anemia (AIHA), more frequently associated with drugs such as cephalosporins, penicillin, non-steroidal anti-inflammatory drugs (NSAIDs), and certain chemotherapeutic agents. The condition is often underdiagnosed due to marked variability in antibody type and affinity, resulting in inconsistent serological findings. Such delays increase the risk of hemolytic crisis, which may result in target end-organ failure or death.
View Article and Find Full Text PDFPediatr Nephrol
September 2025
Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Background: Kidney involvement in pediatric sarcoidosis is rare and often underrecognized, leading to diagnostic delays and treatment challenges. We report six patients with renal sarcoidosis to highlight their diverse presentations and outcomes and challenges in management.
Methods: Medical records of patients diagnosed with renal sarcoidosis during 2020-24 were reviewed.
Semin Nephrol
September 2025
Division of Nephrology, Internal Medicine, University of Michigan, Ann Arbor, MI. Electronic address:
Despite intensive research efforts, acute kidney injury (AKI) is a common clinical syndrome that has limited treatment options apart from supportive care. The increasing availability of molecular interrogation data from patients with Acute Kidney Injury provides an unparalleled opportunity to leverage systems biology approaches. In this review, we discuss the challenges with AKI research, explain how systems biology approaches can link molecular data to clinical phenotypes, review available molecular interrogation tools and techniques, and provide examples where systems biology approaches have been successfully applied in nephrology.
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