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A novel machine learning approach predicts the impact of tumor mutations on cellular phenotypes, overcomes limited training data, minimizes costly functional validation, and advances efforts to implement cancer precision medicine.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357215 | PMC |
http://dx.doi.org/10.1158/0008-5472.CAN-21-3798 | DOI Listing |
Eur J Case Rep Intern Med
August 2025
Department of Gastroenterology and Hepatology, University of Balamand, Beirut, Lebanon.
Unlabelled: Aortic dissection is a life-threatening cardiovascular emergency, particularly Stanford type A, which typically necessitates urgent surgical intervention. Despite advances in surgical techniques and perioperative care, preoperative bleeding and coagulopathy remain significant challenges. Tranexamic acid, an antifibrinolytic agent, is widely used to minimize perioperative bleeding in cardiovascular surgeries; however, its role in the non-surgical, preoperative stabilization of aortic dissection has not been well established.
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August 2025
Division of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
Unlabelled: Encephalitis is a potentially life-threatening condition with infectious or autoimmune aetiologies. Autoimmune encephalitis includes paraneoplastic variants associated with specific onconeural antibodies such as anti-Hu, frequently linked to malignancies. Herpes simplex virus type 1 (HSV-1) is the leading infectious cause in adults.
View Article and Find Full Text PDFPatterns (N Y)
July 2025
Department of Methodology and Statistics, Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, the Netherlands.
ASReview LAB v.2 introduces an advancement in AI-assisted systematic reviewing by enabling collaborative screening with multiple experts ("a crowd of oracles") using a shared AI model. The platform supports multiple AI agents within the same project, allowing users to switch between fast general-purpose models and domain-specific, semantic, or multilingual transformer models.
View Article and Find Full Text PDFAlpha Psychiatry
August 2025
State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, 100875 Beijing, China.
Background: Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental disorder marked by impaired interactions and restricted interests, the pathophysiology of which is not fully understood. The current study explored the potential therapeutic effects of transcranial direct current stimulation (tDCS) on the neurophysiological aspects of ASD, specifically focusing on the brain's excitatory/inhibitory (E/I) balance and behavioral outcomes, providing scientific guidance for ASD intervention.
Methods: Forty-two children with ASD were randomly divided into either an active tDCS or sham tDCS group.
Nat Comput Sci
September 2025
Department of Chemical Engineering, Tsinghua University, Beijing, China.
With approximately 90% of industrial reactions occurring on surfaces, the role of heterogeneous catalysts is paramount. Currently, accurate surface exposure prediction is vital for heterogeneous catalyst design, but it is hindered by the high costs of experimental and computational methods. Here we introduce a foundation force-field-based model for predicting surface exposure and synthesizability (SurFF) across intermetallic crystals, which are essential materials for heterogeneous catalysts.
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