Phytoecdysteroids from L. for Psoriatic Skincare.

Phytoecdysones from seem to be promising agents for skincare in patients with psoriasis. The aim of the study was to determine the effects of creams containing the extract of on psoriatic lesions. Creams with different formulas were prepared: 0-Lekobaza, 1-Lekobaza, , 2-Lekobaza, Salicylic acid, 3-Lekobaza, , Salicylic acid. After examination of skin penetration and biosafety, the designated cream was applied twice daily for 6 weeks on 72 psoriatic plaques located on elbows or knees. The lesions were assessed at baseline and follow-up of 6 weeks. The lesions area was measured, and severity of scaling, erythema, and infiltration was assessed using a 5-point scale (from 0-none to 4-very severe). Skin hydration and structure, pH, transepidermal water loss, erythema, and melanin index were analyzed instrumentally. Creams 1, 2, and 3 significantly reduced the area of psoriatic plaques. Improvement in erythema and infiltration was observed for creams 1 and 3. Creams 1-3 reduced scaling. Our study confirmed a beneficial effect of creams containing extract on psoriatic lesions.