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Article Abstract
A Rh(OAc) catalyzed three-component reaction of vinyl diazosuccinimides with alcohols and isatins has been reported, which provides a practical assess to the direct assembly of succinimide and isatin hybrid molecules in good-to-high yields with excellent stereoselectivity. The antiproliferation activity of these synthesized succinimide and isatin hybrid products has been tested via the CCK8 assay in different cancer cell lines, and compounds 4g (SJSA-1, IC = 3.82 μM) and 4r (HCT-116, IC = 9.02 μM) exhibit higher anticancer potency than other tested compounds.
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