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Granulocyte-colony stimulating factors (G-CSFs) are the cornerstone of peripheral blood stem cell mobilization and apheresis. However, splenic rupture following G-CSF treatment represents a serious and potentially fatal adverse event. Here, we report the case of a patient in their late 50s with severe pancytopenia post-autologous stem cell transplantation reinfusion suffering from splenic rupture after treatment with lenograstim. We also reviewed the literature describing cases of splenic rupture during G-CSF administration.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160916 | PMC |
http://dx.doi.org/10.1177/03000605221095504 | DOI Listing |
Aortoesophageal fistula (AEF) is a rare but life-threatening condition. Initial management typically includes thoracic endovascular aortic repair (TEVAR) or aortic graft replacement to achieve hemostasis, followed by esophagectomy with aortic graft replacement and greater omentum wrapping to eliminate the source of infection. We report a case of successful endoscopic closure of a chronic esophageal fistula secondary to AEF.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Cardiovascular Surgery, Houston Methodist Hospital.
Splenic artery aneurysms (SAA) are the most common visceral aneurysm and may develop significant risk for rupture and life-threatening complications when more than 3 cm, in pregnancy, or if resembling pseudoaneurysms. Traditional treatment options of open surgical repair and endovascular repair have been extensively studied, but the role of robotic-assisted laparoscopic surgery in definitively managing SAA is emerging as a promising minimally invasive alternative in select pathology. This case aims to present the technical details, challenges, and outcomes of an SAA in a young woman treated with robotic-assisted laparoscopic resection, highlighting the feasibility and efficacy of this approach.
View Article and Find Full Text PDFInt Med Case Rep J
August 2025
Department of Pediatric Surgery, Kabul University of Medical Science, Maiwand Teaching Hospital, Kabul, Afghanistan.
Hydatid disease is a zoonotic parasitic infection predominantly caused by the tapeworm . It remains endemic across various regions globally. In nearly 90% of cases, hydatid cysts develop in the liver and lungs; however, other organs, including the spleen, may rarely be affected, particularly in regions with high disease prevalence.
View Article and Find Full Text PDFInt Med Case Rep J
August 2025
Department of Infectious Disease, Tibet Autonomous Region People's Hospital, Lhasa, People's Republic of China.
Infective endocarditis is a severe infectious disease that, in addition to cardiac complications such as heart failure and arrhythmias caused by valve damage, may also lead to extracardiac complications such as septic embolization, metastatic abscesses, and mycotic aneurysms. Here, we report a rare case of splenic infarction resulting from infective endocarditis, subsequently leading to the development of a splenic artery aneurysm three weeks post-surgery confirmed both by CTA and DSA. Following arterial embolization of the aneurysm, the patient eventually recovered completely.
View Article and Find Full Text PDFBMC Med Imaging
August 2025
Department of Radiology, Faculty of Medicine, Aydın Adnan Menderes University, Aydın, Türkiye.
Background: Splenic artery aneurysms (SAAs) are the most common visceral artery aneurysms, often detected incidentally due to the widespread use of cross-sectional imaging. While many remain asymptomatic, rupture carries a high mortality risk. Despite established size-based treatment guidelines, the impact of morphological features, vascular anatomical factors, and comorbidities on SAA growth remains unclear.
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