Molecular Analysis of Caprine Enterovirus Circulating in China during 2016-2021: Evolutionary Significance.

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State Key Laboratory for Zoonotic Diseases, Key Laboratory of Zoonosis Research of Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun 130012, China.

Published: May 2022


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Article Abstract

Here, we report the characterization of 13 novel caprine/ovine enterovirus strains isolated from different regions in China during 2016-2021. Immunoperoxidase monolayer assay showed that these viral strains shared strong cross-reaction with the previously reported caprine enterovirus CEV-JL14. Alignment analysis of the complete nucleotide sequences revealed 79.2%-87.8% and 75.0%-76.7% sequence identity of these novel caprine enterovirus strains to CEV-JL14 and TB4-OEV, respectively. Phylogenetic analyses clustered these novel strains to EV-G based on the amino acid sequences of P1 and 2C+3CD. Moreover, phylogenetic analysis of these caprine enterovirus strains identified three new EV-G types using VP1 sequences. These results demonstrate the genetic variations and the evolution of caprine enterovirus.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9143109PMC
http://dx.doi.org/10.3390/v14051051DOI Listing

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