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http://dx.doi.org/10.1093/annweh/wxac036 | DOI Listing |
BMJ Paediatr Open
September 2025
Division of Medical Critical Care, Boston Children's Hospital, Boston, Massachusetts, USA.
Background: Limited evidence exists on the additive risk of bradycardia in children with respiratory syncytial virus (RSV) bronchiolitis receiving dexmedetomidine (DMED). We aim to study the association between RSV bronchiolitis and bradycardia during DMED administration.
Methods: This retrospective cohort study included 273 children under 2 years old admitted to the intensive care units at Boston Children's Hospital with severe bronchiolitis and sedated with DMED from 2009 to 2022.
In Silico Pharmacol
September 2025
Department of Pharmacoinformatics, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S.A.S Nagar, Mohali, Punjab 160062 India.
Unlabelled: The global health crisis caused by SARS-CoV-2 underscores the urgent need for effective antiviral therapeutics. The SARS-CoV-2 main protease (Mpro) is a crucial enzyme in viral replication, making it a prime target for drug development. In this study, we designed and evaluated peptide inhibitors targeting Mpro by introducing systematic mutations in the Nsp10/11 cleavage site peptide (QLMPER).
View Article and Find Full Text PDFPLoS One
September 2025
Department of Nursing, Faculty of Health Sciences, University of Jaen, Jaen, Spain.
Background: Stressful events of great magnitude have produced significant changes in society and in health education. University students have faced considerable challenges both during and after such events, which have affected their lifestyles, mental health, the development of academic activities, and changes in education systems due to the adoption of new teaching models and the use of online technology.
Objectives: To explore the perspectives and experiences of university health sciences students regarding their lifestyles and academic stress both during and after the COVID-19 pandemic, a highly stressful event.
Front Cell Infect Microbiol
September 2025
Infectious Diseases and Oncology Research Institute, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
The escalating cancer burden in Sub-Saharan Africa (SSA), with projected doubling of incidence and mortality by 2040, necessitates innovative, cost-effective strategies for prevention, diagnosis, and treatment. While known infectious triggers like HPV, hepatitis viruses, and account for an estimated 28.7% of cancers in SSA, the full scope of microbially-mediated oncogenesis remains underexplored.
View Article and Find Full Text PDFBackground: A significant contributory factor to the brachycephalic obstructive airway syndrome index of bulldogs is the diameter of their tracheas. Bulldogs are predisposed to tracheal hypoplasia. A non-invasive, financially reasonable and widely accessible screening test for tracheal diameter would be useful for assessing the most appropriate dogs to breed from within bulldog populations and may help in predicting results following upper airway surgery.
View Article and Find Full Text PDF