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A new thermally activated delayed fluorescence (TADF) compound based on a donor-acceptor (D-A) architecture (D = phenoxazine; A = dibenzo[]phenazine) has been developed, and its photophysical properties were characterized. The D-A compound is applicable as an emitting material for efficient organic light-emitting diodes (OLEDs), and its external quantum efficiency (EQE) exceeds the theoretical maximum of those with prompt fluorescent emitters. Most importantly, comparative study of the D-A molecule and its D-A-D counterpart from the viewpoints of the experiments and theoretical calculations revealed the effect of the number of the electron donor on the thermally activated delayed fluorescent behavior.
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http://dx.doi.org/10.3762/bjoc.18.48 | DOI Listing |
J Med Chem
September 2025
Encoded Technologies, Molecular Modalities Discovery, GSK, Cambridge, Massachusetts 02140, United States.
DNA-encoded libraries (DELs) are used throughout small-molecule drug discovery to identify new lead compounds for protein targets. DEL hits are traditionally evaluated via off-DNA resynthesis and subsequent biological testing. This approach can be time- and resource-intensive, limiting the number of putative hits selected for follow-up.
View Article and Find Full Text PDFJ Agric Food Chem
September 2025
The State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Road, Wuxi 214122, China.
This study develops a multienzyme coimmobilization strategy on NTA-functionalized ZIF-8-coated magnetic nanoparticles (NZMNPs) for efficient d-allulose synthesis. Under optimized immobilization conditions (enzyme-to-carrier ratio: 1:50 w/w, 30 min immobilization), the system achieved an immobilization efficiency of 93.7% along with 107.
View Article and Find Full Text PDFPlant Foods Hum Nutr
September 2025
Graduate School of Food and Nutritional Sciences, Toyo University, 48-1, Oka, 351-8501, Asaka, Saitama, Japan.
Pea shoots (Pisum sativum) are well known to have nutritional benefits when consumed raw; however, the effects of home cooking on their bioactive compounds remain unclear. Therefore, we investigated how different cooking methods affect the antioxidant activity and stability of antioxidants. Our evaluation revealed that antioxidant activity is preserved by steaming but significantly reduced by microwaving and boiling, which also causes weight loss during cooking.
View Article and Find Full Text PDFOrg Biomol Chem
September 2025
Division of Chemistry and Chemical Engineering, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.
In an attempt to react aminocyclopropenones with cyclic imines in order to synthesise amido-substituted pyrrolizidine natural products, we found that aminocyclopropenones undergo a previously unreported stereospecific and regiospecific catalyst-free, thermal ring-opening reaction with alcohols to yield β-enamino esters (also known as vinylogous carbamates or aminoacrylates). We report 21 examples in 45 to 97% isolated yield. The reaction occurs nucleophilic attack at the cyclopropenone carbonyl followed by regiospecific ring opening of the cyclopropenone with retention of alkene geometry.
View Article and Find Full Text PDFAdv Mater
September 2025
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, P. R. China.
Helicene-based circularly polarized luminescence (CPL) materials suffer from severely low color purity in circularly polarized organic light-emitting diodes (CP-OLEDs). Here, a novel molecular engineering strategy is introduced by replacing helicene containing continuous fused benzene rings with a multiple resonance (MR) framework comprising discontinuous fused benzene rings. This approach effectively suppresses high-frequency C─C bond stretching vibrations and enhances short-range charge transfer, enabling high color purity, CPL activity, and efficient thermally activated delayed fluorescence (TADF).
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