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Gupta R, Ray S. Advances in Microcirculatory Assessment: A Game Changer in Sepsis Management or the Latest Fad? Indian J Crit Care Med 2022;26(3):261-263.
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http://dx.doi.org/10.5005/jp-journals-10071-24162 | DOI Listing |
Front Mol Biosci
August 2025
Department of Nephrology, The First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Acute kidney injury is a clinical syndrome characterized by a rapid decline in renal function, driven by pathological mechanisms such as renal tubular epithelial cell injury, inflammatory responses, and microcirculatory dysfunction. In recent years, the role of angiogenesis in AKI recovery and regeneration has gained increasing attention. Angiogenesis plays a dual role in tissue repair and pathological remodeling, exhibiting complex spatiotemporal dynamics during AKI progression.
View Article and Find Full Text PDFInt J Cardiol
September 2025
Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, USA.
Background: Coronary microvascular dysfunction (CMD) contributes to angina without obstructive coronary artery disease (ANOCA). Although aging is known to impact cardiovascular health, its effect on coronary microvascular function remains unclear. This study examined the relationship between age and microvascular function in patients with ANOCA.
View Article and Find Full Text PDFJ Biomech Eng
September 2025
Department of Biomedical Engineering, Technion - IIT, Haifa 32000, Israel.
The pulmonary capillary network (PCN) is a highly complex and dynamic structure essential for gas exchange and systemic homeostasis. Beyond its primary role in oxygen transport, the PCN also mediates a range of transport processes relevant to both health and disease. Scientific interest in the PCN has evolved considerably over time, from early efforts characterizing its anatomy and architecture to modern investigations of its in situ microcirculatory dynamics using advanced imaging technologies.
View Article and Find Full Text PDFJ Clin Med
August 2025
Division of Cardiology, Parma University Hospital, 43126 Parma, Italy.
Ischemia with non-obstructive coronary arteries (INOCA) is a chronic coronary condition associated with poor prognosis and reduced quality of life. The increasing use of invasive assessments of microcirculatory function and provocative spasm testing has significantly advanced the understanding of INOCA's pathophysiology, which ranges from coronary microvascular dysfunction to vasomotor disorders. However, the optimal management and therapeutic approach for INOCA remain to be determined.
View Article and Find Full Text PDFMicrovasc Res
November 2025
Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia.
Background: Refractory no-reflow correlates with worse outcomes, including larger infarct sizes, impaired ventricular function, and higher mortality rates, despite advances in percutaneous coronary intervention (PCI). Microvascular obstruction (MVO) and increased left ventricular end-diastolic pressure (LVEDP) are implicated in the pathogenesis, potentially exacerbating ischemic injury and limiting myocardial recovery. While pressure-wire-derived indices such as the Index of Microcirculatory Resistance (IMR) have been validated against MRI-defined MVO in STEMI populations, their invasive nature and procedural complexity limit broad adoption.
View Article and Find Full Text PDF