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A variety of evidence demonstrates that memory is a reconstructive process prone to errors and distortions. However, the complex relationship between memory encoding, strength of memory reactivation, and the likelihood of reporting true or false memories has yet to be ascertained. We address this issue in a setting that mimics a real-life experience: We asked participants to take a virtual museum tour in which they freely explored artworks included in the exhibit, while we measured the participants' spontaneous viewing time of each explored artwork. In a following memory reactivation phase, participants were presented again with explored artworks (reactivated targets), followed by novel artworks not belonging to the same exhibit (activated lures). For each of these objects, participants provided a reliving rating that indexed the strength of memory reactivation. In the final memory recognition phase, participants underwent an old/new memory task, involving reactivated vs. baseline (i.e., non-reactivated) targets, and activated and baseline lures. The results showed that those targets that were spontaneously viewed for a longer amount of time were more frequently correctly recognized. This pattern was particularly true for reactivated targets associated with greater memory strength (a higher reliving rating). Paradoxically, however, lures that were presented after targets associated with higher reliving ratings in the reactivation phase were more often erroneously recognized as artworks encountered during the tour. This latter finding indicates that memory intrusions, irrespective of the viewing time, are more likely to take place and be incorporated into true memories when the strength of target memory is higher.
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http://dx.doi.org/10.3389/fpsyg.2022.869336 | DOI Listing |
MedComm (2020)
September 2025
Alzheimer's disease (AD) is one of the leading causes of dementia in the elderly, and no effective treatment is currently available. Cathepsin B (CTSB) is involved in key pathological processes of AD, but the underlying mechanisms and its relevance to AD diagnosis and treatment remain unclear. In the present study, we found that CTSB expression was abnormally elevated in the hippocampus of 3×Tg mice and was regulated by miR-96-5p.
View Article and Find Full Text PDFFront Cell Neurosci
August 2025
Memory Research Laboratory, Brain Institute and Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, Brazil.
Object recognition memory (ORM) allows animals to distinguish between novel and familiar items. When reactivated during recall in the presence of a novel object, a consolidated ORM can be destabilized and linked to that generated by the novel object through reconsolidation. The CA1 region of the dorsal hippocampus contributes to ORM destabilization and reconsolidation, with mechanisms involving theta/gamma cross-frequency coupling (hPAC) and synaptic plasticity modulation.
View Article and Find Full Text PDFJ Immunol
September 2025
Ronald O. Perelman Department of Dermatology, NYU Grossman School of Medicine, New York, NY 10016, United States.
Tissue resident memory T cells (TRM) provide protection against local re-infection, and yet the interstitial signals that govern their formation and persistence remain poorly defined. Here, we show that antigen-dependent induction of the chemokine receptor CXCR6, is a conserved adaptation to peripheral tissue infiltration that promotes TRM formation after viral infection. Deficient TRM formation in the absence of CXCR6 was not explained by trafficking as CXCR6 was not required for tissue entry, was dispensable for the early accumulation of antigen-specific CD8+ T cells in skin, and did not restrain their exit.
View Article and Find Full Text PDFTrends Cogn Sci
September 2025
Department of Psychology, The University of Hong Kong, Hong Kong; HKU-Shenzhen Institute of Research and Innovation, Shenzhen, China. Electronic address:
Sleep is not merely a passive state: it actively consolidates memories via reactivation of recent experiences. Beyond preserving precious memories, sleep provides a critical, yet underappreciated window for editing aversive memories. We propose an integrative framework for sleep-based memory editing, outlining three key strategies: extinction via reactivation of original memories, interference reactivation via strengthening of wakeful interfering memories, and interference induction via the introduction of new stimuli during sleep reactivation.
View Article and Find Full Text PDFNat Sci Sleep
August 2025
Department of Psychology and Cognitive Neuroscience Program, Northwestern University, Evanston, IL, USA.
Insights into the mysteries of dreaming and waking conscious experience can be gained by considering fundamental concepts in memory research. To support this assertion, we first provide an overview of the conscious/nonconscious distinction in memory research and then summarize the memory theory of consciousness (MToC). According to the MToC, the brain system responsible for explicit memory is also responsible for all our conscious experiences-perceptions, thoughts, memories, imaginings, and dreams.
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