Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Saturated bicycles are becoming ever more important in the design and development of new pharmaceuticals. Here a new strategy for the synthesis of bicyclo[2.1.1]hexanes is described. These bicycles are significant because they have defined exit vectors, yet many substitution patterns are underexplored as building blocks. The process involves sensitization of a bicyclo[1.1.0]butane followed by cycloaddition with an alkene. The scope and mechanistic details of the method are discussed.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9832330 | PMC |
| http://dx.doi.org/10.1021/jacs.2c02976 | DOI Listing |
Publication Analysis
Top Keywords
synthesis bicyclo[211]hexanes
8
strain-release [2π
4
[2π 2σ]
4
2σ] cycloadditions
4
cycloadditions synthesis
4
bicyclo[211]hexanes initiated
4
initiated energy
4
energy transfer
4
transfer saturated
4
saturated bicycles
4