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Article Abstract
In this study, a bioguided fractionation of extract was performed by chromatographic methods. It yielded one new -abietane diterpene, mutabilol (), and three known abietanes, coleon-U-quinone (), 8α,9α-epoxycoleon-U-quinone (), and coleon U (). The abietane diterpenoid was also tentatively identified using HPLC-MS/MS. Moreover, the extract profile and quantification of each isolated compound were determined by HPLC-DAD. Compound was the major compound in the extract. Compounds - were found to be selective toward cancer cell lines and were able to inhibit P-glycoprotein (P-gp) activity in NCI-H460/R cells at longer exposure of 72 h and consequently revert doxorubicin (DOX) resistance in subsequent combined treatment. None of the compounds influenced the P-gp expression in NCI-H460/R cells, while the extract significantly increased it.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9014510 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.1c00711 | DOI Listing |
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