98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1056/NEJMcpc2115855 | DOI Listing |
Nat Commun
July 2025
Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Infections of the dental pulp are common sequelae of microbial activity and host susceptibility, affecting >80% of adult population. We performed a genome-wide association study on endodontic infections utilizing Finnish health registry and genotype data from FinnGen. Cases [132,124 (27.
View Article and Find Full Text PDFJ Robot Surg
June 2025
Department of Gynecologic Specialty Surgery, Columbia University Irving Medical Center-New York Presbyterian Hospital, 622 West 168th St., New York, NY, USA.
An isthmocele, also called a cesarean scar defect or niche, is a defect in the lower uterine segment myometrium that occurs as a result of a cesarean delivery. This study aims to review our institution's comprehensive data following robotic-assisted laparoscopic isthmocele repair (RA-IR) including birth outcomes and changes in the dimensions of the isthmocele. This was a retrospective case series at a single high-volume tertiary medical center in the United States with over 2500 gynecologic surgeries performed yearly.
View Article and Find Full Text PDFMol Neurodegener
April 2025
Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Biallelic loss-of-function variants in TYROBP and TREM2 cause autosomal recessive presenile dementia with bone cysts known as Nasu-Hakola disease (NHD, alternatively polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy, PLOSL). Some other TREM2 variants contribute to the risk of Alzheimer's disease (AD) and frontotemporal dementia, while deleterious TYROBP variants are globally extremely rare and their role in neurodegenerative diseases remains unclear. The population history of Finns has favored the enrichment of deleterious founder mutations, including a 5.
View Article and Find Full Text PDFBiomedicines
March 2025
Faculty of Medicine, University of Medicine and Pharmacy Carol Davila, 020021 Bucharest, Romania.
-related myelodysplastic syndrome (-MDS) is a unique predisposition syndrome with a high risk of leukemic transformation. This systematic review synthesizes current literature and presents two illustrative pediatric -MDS cases. Data retrieval from eight cohort and case-control studies provides comprehensive analysis on disease features, diagnostic complexities, management, and outcomes related to hematopoietic stem cell transplantation (HSCT) in -related myeloid malignancies.
View Article and Find Full Text PDFHead Neck Pathol
April 2025
Department of Otolaryngology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Purpose: Limited data from genome-wide association studies (GWAS) focusing on oral tongue squamous cell carcinoma (OTSCC) are available. The present study was conducted to explore genetic associations for OTSCC.
Methods: A GWAS on 376 cases of OTSCC was conducted using the FinnGen Data Freeze-12 dataset.