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http://dx.doi.org/10.1158/1078-0432.CCR-22-0564 | DOI Listing |
Pediatr Res
July 2025
ISGlobal, Barcelona, Spain.
Background And Objectives: Meningitis diagnosis requires a lumbar puncture (LP) to obtain cerebrospinal fluid (CSF) for a laboratory-based analysis. In high-income settings, LPs are part of the systematic approach to screen for meningitis, and most yield negative results. In low- and middle-income settings, LPs are seldom performed, and suspected cases are often treated empirically.
View Article and Find Full Text PDFPharm Res
July 2025
Small Molecule Research, Alexion, AstraZeneca Rare Disease, 100 College St, New Haven, 06510, CT, USA.
Sci Rep
July 2025
Aix Marseille Univ, INSERM UA16, Marseille, France.
Nutrients
May 2025
Molecular Oncology Group, IMDEA Food Institute, CEI UAM+CSIC, 28049 Madrid, Spain.
: Obesity, mainly visceral obesity, causes a low-grade of chronic inflammation (meta-inflammation), associated with comorbidities such as type 2 diabetes, cardiovascular diseases, and certain cancers. Precision Nutrition aims to understand the bidirectional crosstalk between the genome and diet to improve human health. Additionally, by leveraging individual data, Precision Nutrition seeks to predict how people will respond to specific foods or dietary patterns, with the ultimate goal of providing personalized nutritional recommendations tailored to their unique needs and lifestyle factors, including poor dietary habits (e.
View Article and Find Full Text PDFJ Am Heart Assoc
May 2025
Department of Pharmacology and Personalised Medicine School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University Maastricht The Netherlands.
Background: Most human disease definitions, except for rare and communicable diseases, are based on symptoms in specific organs, not on causal molecular mechanisms. This limits treatments to imprecise symptomatic approaches with high numbers needed to treat. Systems medicine, instead, has a holistic approach and defines diseases in an organ-agnostic manner on the basis of associated risk genes, their encoded proteins, and protein-protein interactions.
View Article and Find Full Text PDF