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Induction motors tend to have better efficiency on rated conditions, but at partial load conditions, when these motors operate on rated flux, they exhibit lower efficiency. In such conditions, when these motors operate for a long duration, a lot of electricity gets consumed by the motors, due to which the computational cost as well as the total running cost of industrial plant increases. Squirrel-cage induction motors are widely used in industries due to their low cost, robustness, easy maintenance, and good power/mass relation all through their life cycle. A significant amount of electrical energy is consumed due to the large count of operational units worldwide; hence, even an enhancement in minute efficiency can direct considerable contributions within revenue saving, global electricity consumption, and other environmental facts. In order to improve the efficiency of induction motors, this research paper presents a novel contribution to maximizing the efficiency of induction motors. As such, a model of induction motor drive is taken, in which the proportional integral (PI) controller is tuned. The optimal tuning of gains of a PI controller such as proportional gain and integral gain is conducted. The tuning procedure in the controller is performed in such a condition that the efficiency of the induction motor should be maximum. Moreover, the optimization concept relies on the development of a new hybrid algorithm, the so-called Scrounger Strikes Levy-based dragonfly algorithm (SL-DA), that hybridizes the concept of dragonfly algorithm (DA) and group search optimization (GSO). The proposed algorithm is compared with particle swarm optimization (PSO) for verification. The analysis of efficiency, speed, torque, energy savings, and output power is validated, which confirms the superior performance of the suggested method over the comparative algorithms employed.
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http://dx.doi.org/10.3390/s22072594 | DOI Listing |
EMBO Mol Med
September 2025
Department of Neurology, Columbia University, New York, NY, 10032, USA.
Spinal muscular atrophy (SMA) is a neurodegenerative disease caused by ubiquitous deficiency in the SMN protein. The identification of disease modifiers is key to understanding pathogenic mechanisms and broadening the range of targets for developing SMA therapies that complement SMN upregulation. Here, we report a cell-based screen that identified inhibitors of p38 mitogen-activated protein kinase (p38 MAPK) as suppressors of proliferation defects induced by SMN deficiency in mouse fibroblasts.
View Article and Find Full Text PDFJAMA Netw Open
September 2025
Perinatal Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Importance: Exposure to inflammation from chorioamnionitis places the fetus at higher risk of premature birth and may increase the risk of neurodevelopmental impairments, though the evidence for the latter is mixed.
Objective: To evaluate whether moderate to severe histologic chorioamnionitis (HCA) is directly associated with adverse motor performance, independent of the indirect mediating effects of premature birth.
Design, Setting, And Participants: This prospective, population-based cohort study recruited participants between September 16, 2016, and November 19, 2019, from referral and nonreferral neonatal intensive care units of 5 southwestern Ohio hospitals.
Brain
September 2025
Central European Institute of Technology Masaryk University (CEITEC MU), 625 00 Brno, Czech Republic.
Mutations in the human ADAR gene encoding adenosine deaminase acting on RNA 1 (ADAR1) cause Aicardi-Goutières syndrome 6 (AGS6); a severe auto-inflammatory encephalopathy with aberrant interferon (IFN) induction. AdarΔ2-13 null mutant mouse embryos lacking ADAR1 protein die with high levels of IFN-stimulated gene (ISG) transcripts. In Adar Mavs double mutants also lacking the Mitochondrial antiviral signaling (MAVS) adaptor, the aberrant IFN induction is prevented.
View Article and Find Full Text PDFAnesth Analg
September 2025
From the Department of Neurosurgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Background: Transcranial electrical stimulation muscle-recorded motor evoked potentials (Tc-mMEPs) are used to monitor the spinal cord motor tracts during spinal surgery. There is considerable intra- and interindividual variability in the signals recorded, causing a high incidence of false positive warnings. Inadequate blood pressure is commonly blamed for false positive warnings and is usually managed with fluid and vasopressor therapy.
View Article and Find Full Text PDFGait Posture
September 2025
UHasselt, REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Wetenschapspark 7, Diepenbeek 3590, Belgium. Electronic address:
Objective: Although emotions and postural control are strongly intertwined, more research is necessary to understand this intricate relationship. Therefore, we examined the effect of script-driven emotional imagery on postural control in healthy individuals.
Methods: Forty-four healthy participants (50 % female, median age=27) imagined three emotional imagery scripts (hostile, acceptance, relaxation) in upright standing without visual input while center of pressure (CoP) was measured (mean sway, sway velocity, , and standard deviation in antero-posterior and medio-lateral directions, and sway path and area).