Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We report on the design and synthesis of triptycene-peptide hybrids (TPHs), , -, and -, which are conjugates of a triptycene core unit with two or three cationic KKKGG peptides (K: lysine and G: glycine) through a C alkyl chain. It was discovered that - and - induce paraptosis, a type of programmed cell death (PCD), in Jurkat cells (leukemia T-lymphocytes). Mechanistic studies indicate that these TPHs induce the transfer of Ca from the endoplasmic reticulum (ER) to mitochondria, a loss of mitochondrial membrane potential (ΔΨ), tethering of the ER and mitochondria, and cytoplasmic vacuolization in the paraptosis processes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.bioconjchem.2c00076 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toward Human-Centered Artificial Intelligence for Users' Digital Well-Being: Systematic Review, Synthesis, and Future Directions.
JMIR Hum Factors
September 2025
Seidenberg School of Computer Science and Information Systems, Pace University, New York City, NY, United States.
Background: As information and communication technologies and artificial intelligence (AI) become deeply integrated into daily life, the focus on users' digital well-being has grown across academic and industrial fields. However, fragmented perspectives and approaches to digital well-being in AI-powered systems hinder a holistic understanding, leaving researchers and practitioners struggling to design truly human-centered AI systems.
Objective: This paper aims to address the fragmentation by synthesizing diverse perspectives and approaches to digital well-being through a systematic literature review.
Design and synthesis of novel indolinone Aurora B kinase inhibitors based on fragment-based drug discovery (FBDD).
Mol Divers
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, China.
Aurora kinases are a group of serine/threonine kinases essential for cell mitosis, comprising Aurora A, B, and C. However, the Aurora B is overexpressed in multiple tumors and the aurone has been proved to exhibit potent inhibitory activity against Aurora B kinase by our group. The indolinone was considered as an aurone scaffold hopping analog, and the indolinone-based Aurora B inhibitor library (3577 molecules) was constructed by FBDD strategy.
View Article and Find Full Text PDFIn silico design, synthesis of a novel chalcone derivative and its in vitro and in vivo anticancer activity against colon cancer-induced mouse model.
Naunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Pharmacology, Acharya & BM Reddy College of Pharmacy, Acharya Dr. Sarvepalli Radhakrishna Road, Achit Nagar (Post), Soldevanahalli, Bengaluru, 560107, India.
This study aimed to synthesize and evaluate the anticancer activity of novel chalcone derivative against colon cancer by in vitro cytotoxicity against HCT-116 (Research Resource Identifiers:CVCL_D4JB) cell line and in vivo using EAC (Research Resource Identifiers: CVCL_1306) and DLA (Research Resource Identifiers: CVCL_VR37) cells inoculated Swiss albino mice. The present study aimed to synthesize the new chalcone derivatives and conduct its anti-colon cancer activity both in vitro and in vivo. The designed compounds were subjected to in silico studies like binding pocket analysis, molecular docking, and ADME studies.
View Article and Find Full Text PDFEnvironmentally friendly synthesis of carbon quantum dots (CQDs) to enhance photocatalytic activity for the photodegradation of various organic dyes and the evolution of hydrogen and oxygen.
J Fluoresc
September 2025
Chemical Engineering Department, College of Engineering, University of Ha'il, P.O. Box 2440, 81441, Ha'il, Saudi Arabia.
This review delivers a focused and critical evaluation of recent progress in the green synthesis of carbon quantum dots (CQDs), with particular attention to state-of-the-art approaches utilizing renewable biomass as precursors. The main objective is to systematically examine innovative, environmentally friendly methods and clarify their direct influence on the core properties and photocatalytic performance of CQDs. The novelty of this review stems from its comprehensive comparison of green synthetic pathways, revealing how specific processes determine key structural, optical, and electronic attributes of the resulting CQDs.
View Article and Find Full Text PDFHave We Been Measuring Migrant Wellbeing all Wrong? Conceptualizing Migrant Wellbeing: A Systematic Review.
J Immigr Minor Health
September 2025
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
Wellbeing is a widely used concept yet lacks a universal definition and standardized measurement. Migrants, especially those forcibly displaced, face challenges that impact their quality of life and wellbeing. To understand how the wellbeing of people who migrate from low/middle-income countries to middle/high-income countries has been conceptualized, defined, and measured.
View Article and Find Full Text PDF