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Causal relationships, unlike mere co-occurrence, allow humans to obtain rewards and avoid punishments by intervening on their environment. Accordingly, explicit (controlled) evaluations of stimuli encountered in the environment are known to be sensitive to causal relationships above and beyond mere co-occurrence. In this project, we conduct stringent tests of whether implicit (automatic) evaluation also reflects causal relationships and begin to probe the representational mechanisms underlying such sensitivity. Participants (N = 4836) observed causal events during which two stimuli were equally contingent with positive or negative outcomes but only one of them was causally responsible for these outcomes. Across 6 studies, varying in design and amount of verbal scaffolding provided, differences in causal status consistently guided not only explicit measures of evaluation (Likert and slider scales; Bayes Factor meta-analysis: Cohen's d = 0.28, BF > 10) but also their implicit counterparts (Implicit Association Tests; Bayes Factor meta-analysis: Cohen's d = 0.22, BF > 10). However, unlike their explicit counterparts, implicit evaluations were not sensitive to causal relationships that had to be flexibly derived by combining disparate past experiences. Taken together, these studies suggest that implicit evaluations are sensitive to causal information. Such sensitivity seems to be mediated via precompiled, causally informed value representations rather than online computations over a causal model.
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http://dx.doi.org/10.1016/j.cognition.2022.105116 | DOI Listing |
Clin Anat
September 2025
Department of Communication Disorders and Sciences, Rush University Medical Center, Chicago, Illinois, USA.
This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as gleaned from death certificates. HFI is an irregular bony overgrowth of the endocranial surface of the frontal bone.
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September 2025
Department of Biomedical Sciences, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.
Cancer is a multifaceted disease driven by a complex interplay of genetic predisposition, environmental factors and lifestyle habits. With the accelerating pace of cancer research, the gut microbiome has emerged as a critical modulator of human health and immunity. Disruption in the gut microbial populations and diversity, known as dysbiosis, has been linked with the development of chronic inflammation, oncogenesis, angiogenesis and metastasis.
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September 2025
Guangxi Key Laboratory of AIDS Prevention and Treatment & School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Background: People living with HIV(PLWH) are a high-risk population for cancer. We conducted a pioneering study on the gut microbiota of PLWH with various types of cancer, revealing key microbiota.
Methods: We collected stool samples from 54 PLWH who have cancer (PLWH-C), including Kaposi's sarcoma (KS, n=7), lymphoma (L, n=22), lung cancer (LC, n=12), and colorectal cancer (CRC, n=13), 55 PLWH who do not have cancer (PLWH-NC), and 49 people living without HIV (Ctrl).
Front Immunol
September 2025
Institute of Pulmonary Medicine, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Neutrophil extracellular traps (NETs) are DNA-protein structures released during a form of programmed neutrophil death known as NETosis. While NETs have been implicated in both tumor inhibition and promotion, their functional role in cancer remains ambiguous. In this study, we compared the NET-forming capacity and functional effects of NETs derived from lung cancer (LC) patients and healthy donors (H).
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September 2025
Department of Pathological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, United States.
Oncolytic virotherapy (OVT) has emerged as a promising and innovative cancer treatment strategy that harnesses engineered viruses to selectively infect, replicate within, and destroys malignant cells while sparing healthy tissues. Beyond direct oncolysis, oncolytic viruses (OVs) exploit tumor-specific metabolic, antiviral, and immunological vulnerabilities to reshape the tumor microenvironment (TME) and initiate systemic antitumor immunity. Despite promising results from preclinical and clinical studies, several barriers, including inefficient intratumoral virus delivery, immune clearance, and tumor heterogeneity, continue to limit the therapeutic advantages of OVT as a standalone modality and hindered its clinical success.
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