Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The application of microfluidics technology in additive manufacturing is an emerging approach that makes possible the fabrication of functional three-dimensional cell-laden structured biomaterials. A key challenge that needs to be addressed using a microfluidic-based printhead (MBP) is increasing the controllability over the properties of the fabricated microtissue. Herein, an MBP platform is numerically simulated for the fabrication of solid and hollow microfibers using a microfluidic channel system with high level of controllability over the microfiber geometrical outcomes. Specifically, the generation of microfibers is enabled by studying the effects of microfluidic-based bioprinting parameters that capture the different range of design, bioink material, and process parameter dependencies as numerically modeled as a multiphysics problem. Furthermore, the numerical model is verified and validated, exhibiting good agreement with literature-derived experimental data in terms of microfiber geometrical outcomes. Additionally, a predictive mathematical formula that correlates the dimensionless process parameters with dimensionless geometrical outcomes is presented to calculate the geometrical outcomes of the microfibers. This formula is expected to be applicable for bioinks within a prescribed range of the density and viscosity value. The MBP applications are highlighted towards precision fabrication of heterogeneous microstructures with functionally graded properties to be used in organ generation, disease modeling, and drug testing studies.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888655 | PMC |
| http://dx.doi.org/10.1038/s41598-022-07392-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Measuring multisubunit mechanics of geometrically programmed colloidal assemblies via cryo-EM multi-body refinement.
Proc Natl Acad Sci U S A
September 2025
Martin A. Fisher School of Physics, Brandeis University, Waltham, MA 02453.
Programmable self-assembly has recently enabled the creation of complex structures through precise control of the interparticle interactions and the particle geometries. Targeting ever more structurally complex, dynamic, and functional assemblies necessitates going beyond the design of the structure itself, to the measurement and control of the local flexibility of the intersubunit connections and its impact on the collective mechanics of the entire assembly. In this study, we demonstrate a method to infer the mechanical properties of multisubunit assemblies using cryogenic electron microscopy (cryo-EM) and RELION's multi-body refinement.
View Article and Find Full Text PDF3D Structural Phenotype of the Optic Nerve Head in Glaucoma and Myopia - A Key to Improving Glaucoma Diagnosis in Myopic Populations.
Am J Ophthalmol
September 2025
Singapore Eye Research Institute, Singapore National Eye Centre, Singapore; Duke-NUS Graduate Medical School, Singapore; Department of Ophthalmology, Emory University School of Medicine, Emory University; Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta
Purpose: To characterize the 3D structural phenotypes of the optic nerve head (ONH) in patients with glaucoma, high myopia, and concurrent high myopia and glaucoma, and to evaluate their variations across these conditions.
Design: Retrospective cross-sectional study.
Participants: A total of 685 optical coherence tomography (OCT) scans from 754 subjects of Singapore-Chinese ethnicity, including 256 healthy (H), 94 highly myopic (HM), 227 glaucomatous (G), and 108 highly myopic with glaucoma (HMG) cases METHODS: We segmented the retinal and connective tissue layers from OCT volumes and their boundary edges were converted into 3D point clouds.
Immunogenicity comparison of an -produced 9-valent human papillomavirus vaccine and Gardasil9 in Chinese women aged 18-26 years: three-year follow-up data from a randomised clinical trial.
Lancet Reg Health West Pac
September 2025
State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.
Background: Cecolin9, a second-generation 9-valent HPV vaccine derived from the WHO-prequalified Cecolin, has received marketing authorisation in China in May 2025. The non-inferiority of type-specific immune responses between Cecolin9 and Gardasil9 has been previously established at month 7 in Chinese women aged 18-26 years (NCT04782895). This study aimed to compare the plateau antibody levels between the two vaccines three years post the first dose.
View Article and Find Full Text PDFPlatelet protease-activated receptor 4 genotype and response to aspirin in pregnancy.
Blood Vessel Thromb Hemost
August 2025
Cardeza Foundation for Hematologic Research, Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA.
The platelet protease-activated receptor 4 (PAR4) threonine 120 (Thr120) allele is an activating allele associated with reduced aspirin response in vitro. Aspirin is recommended in high-risk pregnancies to prevent preeclampsia and preterm birth. We evaluated the impact of PAR4 genotype on aspirin response in pregnancy, as measured by platelet function assay 100 (PFA-100) epinephrine closure time, and perinatal outcomes.
View Article and Find Full Text PDFArtificial Intelligence-Driven Automated Design of Anterior and Posterior Crowns Under Diverse Occlusal Scenarios.
J Esthet Restor Dent
September 2025
Department of Prosthodontics, Seoul National University School of Dentistry, Seoul, Republic of Korea.
Objective: To evaluate the impact of occlusion type and artificial intelligence-based computer-aided design (CAD) software on the geometric accuracy and clinical quality of auto-generated anterior and posterior crown designs.
Methods: Five typodont models representing various occlusion types (normal, Class I anterior diastema, Class II division 1, Class II division 2, and Class III anterior crossbite occlusion) underwent crown preparation for the maxillary right central incisor and first molar. Ten sets of intraoral scans were obtained from each prepared model, and crown designs were automatically generated using two software programs: deep learning-based (DL; Dentbird) and conventional automated (CA; Auto Workflow, 3Shape) (n = 10).