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Article Abstract
Natural products and their synthetic analogs and derivatives are a traditional source of bioactive molecules with potential development as drug candidates. In this context, Marine Natural Products (MNPs) represent a rich reservoir of diverse molecular skeletons with potential pharmacological activity that, so far, has been mostly explored in cancer and infectious diseases. Starting from the development of a novel bioassay-guided screening platform for immunomodulatory compounds from an in-house MNPs library, we report the identification of the alkaloid lepadin A as a new model compound for immune-based anticancer activity with characteristics that suggest a possible mechanism as Immunogenic Cell Death inducer. The work describes the molecular-based bioprospecting in the Gulf of Naples together with the bioassay-guided fractionation, the chemical characterization of the alkaloid, and the biological activity in mouse dendritic cells (D1).
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| http://dx.doi.org/10.3390/biom12020246 | DOI Listing |
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Article Synopsis
- Natural products, particularly Marine Natural Products (MNPs), are vital for discovering bioactive molecules with potential drug development, especially for cancer and infectious diseases.
- A new bioassay-guided screening platform was developed to identify immune-boosting compounds from an MNPs library, leading to the discovery of lepadin A as a promising new compound for anticancer activity.
- The study details the process of bioprospecting in the Gulf of Naples, which includes fractionating MNPs, characterizing lepadin A chemically, and evaluating its effects on mouse dendritic cells.
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