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We present the case of a 60-year-old man with a history of severe tophaceous gout with polyarticular involvement who came to the emergency room due to direct trauma to the right forearm and knee. The knee X-ray and CT scan showed a lateral tibial plateau fracture characterized by the presence of a lytic bone lesion. The presence of a solid neoplasm was ruled out and a CT-guided biopsy was performed. Histological evaluation revealed findings typical for an advanced intraosseous gout. As there was no significant risk of progression of the lytic lesion, the fracture site was treated conservatively. This case is unique in the literature in terms of location and should be considered as an atypical site of intraosseous gout. Proper differentiation of a pathological fracture on an intraosseous gout location from a neoplastic lesion is essential to choose the correct therapy.
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http://dx.doi.org/10.1016/j.radcr.2022.01.005 | DOI Listing |
Cureus
June 2025
Internal Medicine, Services Hospital Lahore, Lahore, PAK.
Background Long-term gout patients have been linked to increased risk of coronary heart disease (CHD) and its associated comorbidities. Therefore, careful evaluations are necessary to examine the prevalence and the causes of CHD in gout patients. The aim of this research was to identify significant factors associated with CHD in patients with gout along with the prevalence rate.
View Article and Find Full Text PDFCureus
April 2025
Orthopedics and Traumatology, Hospital Regional Elvia Carrillo Puerto, Institute for Social Security and Services for State Workers (ISSSTE) Facultad de Medicina de la Universidad Autónoma de Yucatán, Merida, MEX.
Gout is an inflammatory arthritis caused by monosodium urate crystal deposition, leading to progressive joint destruction and functional impairment. While pharmacologic treatment remains the standard, advanced cases with intra-articular and intraosseous tophi may require surgical intervention. Total knee arthroplasty (TKA) has been reported as a viable option for managing severe tophaceous gout with structural bone defects, improving joint function and pain control when conservative therapy fails.
View Article and Find Full Text PDFDokl Biochem Biophys
August 2024
Nasonova Research Institute of Rheumatology, Moscow, Russia.
Unlabelled: Gout is associated with increased risk of cardiovascular disease (CVD) morbidity and mortality. Therefore, an association between coronary heart disease (CHD) and gout deserves careful examination.
Aim: .
J Am Podiatr Med Assoc
December 2022
*Department of Orthopedic Surgery, Jeonbuk National University Medical School, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, South Korea.
Tophaceous gout often occurs in soft tissues, and gouty invasion to the bone is rare. To date, only one case of isolated intraosseous gouty invasion to the calcaneus has been reported. We report here a rare case of an intraosseous calcaneal gouty cystic lesion treated with curettage and allogenous and autogenous bone graft.
View Article and Find Full Text PDFRadiol Case Rep
April 2022
Department of Diagnostic and Interventional Radiology, University of Insubria, Medical Clinical Institute Intermedica - Columbus, via Buonarroti 48, Varese, 20145, Italy.