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Myopia represents a major socioeconomic burden with an increasing prevalence worldwide. Pathologic myopia refers to myopic patients with structural changes in the posterior pole including different patterns of chorioretinal atrophy, choroidal neovascularization (CNV) and vitreomacular tractional diseases. Multifocal choroiditis (MFC) is one of the most frequent noninfectious posterior uveitis, and epidemiologically typically affects young myopic females. Acute and chronic chorioretinal atrophic changes are the hallmark feature of MFC, with CNV developing in almost one third of cases. Thus, differentiation of inflammatory lesions due to MFC or neurodenegerative lesions due to pathologic myopic is key in order to establish a particular prognosis, follow-up schedule, and therapeutic approach. The aim of the present manuscript is to summarize and illustrate the main multimodal imaging features of these diseases.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818887 | PMC |
http://dx.doi.org/10.3389/fmed.2021.831764 | DOI Listing |
Am J Ophthalmol
August 2025
Advanced Eye Centre (V.G.), Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
Cureus
July 2025
Department of Ophthalmology, Medical University of Warsaw, Warsaw, POL.
This case study presents a 51-year-old male diagnosed with relentless placoid chorioretinitis (RPC), a rare condition within the spectrum of inflammatory chorioretinopathies, who experienced progressive vision loss following a COVID-19 infection. The patient's clinical presentation was accompanied by a similar episode, misdiagnosed and untreated, nine years earlier. During clinical evaluation, the patient exhibited overlapping features of acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous choroiditis (SC), and RPC.
View Article and Find Full Text PDFAm J Ophthalmol
August 2025
Advanced Eye Centre (V.G.), Postgraduate Institute of Medical Education and Research, Chandigarh, India. Electronic address:
Purpose: To evaluate a minimum imaging set (MIS) to support ophthalmologists in diagnosing, monitoring disease activity, and identifying disease-specific complications for six types of noninfectious posterior uveitides (NIPU).
Design: Visual questionnaire answered live by a group of ophthalmologists.
Participants: International group of ophthalmologists, including uveitis experts, medical retina experts, general ophthalmologists, and ophthalmologists-in-training.
Adv Exp Med Biol
July 2025
Department of Ophthalmology, Sidney Kimmel Medical College at Thomas Jefferson University, New York, NY, USA.
Noninfectious uveitis syndromes are a heterogeneous group of disorders affecting the retina and choroid. Their etiology is unknown, but some follow a flu-like illness. Autoimmune pathogenesis has also been postulated.
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July 2025
Flinders Health and Medical Research Institute and College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia. Electronic address:
Relentless placoid chorioretinitis (RPC) is a rare, vision-threatening posterior uveitis that predominantly affects young adults. The hallmark clinical findings are numerous scattered placoid chorioretinal lesions involving the midperipheral and far peripheral fundus as well as the posterior pole and a persistent or recurrent course resulting in lesions at different chronological stages, with fresh creamy placoid lesions and healing pigmented lesions being present at the same time. Although RPC is frequently described as a disease that is intermediate between acute posterior multifocal placoid pigment epitheliopathy (APMPPE) and serpiginous choroiditis, it more closely resembles APMPPE.
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