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http://dx.doi.org/10.1016/j.schres.2022.01.032 | DOI Listing |
Eur Neuropsychopharmacol
August 2025
Emeritus Consultant. Barcelona Clínic Schizophrenia Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain.
The study of brain morphology parameters in patients with first-episode psychosis (FEP) could help detect early brain footprints related to this disease and its predominant symptomatology. We examined gray matter (GM) volume, cortical thickness (CT), gyrification index (GI), and sulcus depth (SD) differences between patients with FEP and healthy control (HC) participants. We also investigated the associations of these brain parameters with symptomatology in FEP.
View Article and Find Full Text PDFTransl Psychiatry
August 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Not everyone is equally likely to experience mental illness. What is the contribution of an individual's genetic background and experiences of childhood adversity to that likelihood? And how do these risk factors interact at the level of the brain? This study explores these questions by investigating the relationship between genetic liability for mental illness, childhood adversity, and cortico-limbic connectivity in a large developmental sample drawn from the ABCD cohort (N = 6535). Canonical Correlation Analysis - a multivariate data-reduction technique - revealed two genetic dimensions of mental illness from the polygenic risk scores for ADHD, Anxiety, Depression, and Psychosis.
View Article and Find Full Text PDFSchizophr Bull
August 2025
Department of Psychology, University of California, Irvine, CA 92697, United States.
Background And Hypothesis: Psychosis is a heterogeneous phenomenon that emerges across a severity spectrum. Attenuated psychotic symptoms, or psychotic-like experiences (PLEs), reflect potential risk factors for formal psychosis and other clinical outcomes. There has historically been a widespread misconception that individuals who experience symptoms of psychosis are dangerous and prone to aggressive behavior.
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