Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Calculating patients' medication availability from dispensing or refill data is a common method to estimate adherence. The most often used measures, such as the medication possession ratio (MPR), average medication supplies over an arbitrary period. Averaging masks the variability of refill behavior over time.
Goal: To derive a new absolute adherence estimate from dispensing data.
Method: Dispensing histories of patients with 19 refills of direct oral anticoagulants (DOAC) between 1 January 2008 and 31 December 2017 were extracted from 39 community pharmacies in Switzerland. The difference between the calculated and effective refill day (ΔT) was determined for each refill event. We graphed ΔT and its dichotomized version (dΔT) against the MPR, calculated mean ΔT and mean dΔT per refill, and applied cluster analysis.
Results: We characterized 2204 refill events from 116 DOAC patients. MPR was high (0.975 ± 0.129) and showed a positive correlation with mean ΔT. Refills occurred on average 17.8 ± 27.9 days "too early", with a mean of 75.8 ± 20.2 refills being "on time". Four refill behavior patterns were identified including constant gaps within or at the end of the observation period, which were critical.
Conclusion: We introduce a new absolute adherence estimate ΔT that characterizes every refill event and shows that the refill behavior of DOAC patients is dynamic.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778707 | PMC |
| http://dx.doi.org/10.3390/pharmaceutics14010103 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Penile Entrapment Caused by Five Metallic Rings: A Case Report.
Cureus
July 2025
Urology, Hospital Angeles Metropolitano, Mexico City, MEX.
Penile strangulation is a rare urological emergency that can lead to severe complications such as ischemia, necrosis, and urethral injury. We present a case of a 76-year-old man who presented to the emergency department with severe penile pain and swelling after applying five metallic rings to enhance erection during sexual intercourse. The patient had a history of erectile dysfunction and had been using phosphodiesterase inhibitors with a moderate response.
View Article and Find Full Text PDFLength of stay, pain and opioid consumption following manual versus robotic-assisted total hip arthroplasty.
J Orthop
December 2025
Hospital for Special Surgery, New York, NY, USA.
Background: Robotic assistance in total hip arthroplasty (THA) has increased, but the influence on outcomes compared to manual THA remains uncertain. With the growing emphasis on reducing opioid consumption after arthroplasty, we studied whether robotic assistance was associated with length of stay (LOS), pain, and opioid use after THA.
Materials And Methods: We included 14,501 opioid-naïve patients who underwent THA at a single institution between 2019 and 2023 (8900 manual and 5601 robotic).
Healthcare Practitioner and Other Professionals' Perspectives on Gabapentinoid Misuse and Dependence: A Systematic Review of Qualitative Studies.
Eur J Pain
October 2025
Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia.
Background And Objective: The global rise in gabapentinoid prescriptions for chronic pain has been striking. However, this trend has been accompanied by growing concerns about misuse and dependence. This qualitative systematic review aimed to synthesise the perspectives of healthcare practitioners and other professionals on these emerging challenges.
View Article and Find Full Text PDFStudy on the Effect of the Plunging Depth of Stirring Pin on the Performance of 6061-T6 Aluminum Alloy Refill Friction Stir Spot Welded Zone.
Materials (Basel)
August 2025
College of Mechanical and Electrical Engineering, Huangshan University, Huangshan 245041, China.
In this study, under varying PDSP (plunging depths of stirring pin) and process parameters, refill friction stir spot welding tests were performed on 6061-T6 aluminum alloy, relying on a stirring tool with a 12 mm sleeve diameter and an 8 mm stirring pin diameter. The results manifested the internal defects in the weld zone when PDSP was 0, notwithstanding the alterations in process parameters. However, these flaws disappeared when PDSP was 0.
View Article and Find Full Text PDFPatterns of Benzodiazepines and Hypnotic Drugs Dispensing After Hip Fracture Among Older US Adults Previously on the Drugs.
J Am Geriatr Soc
August 2025
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Background: Benzodiazepines (BZD) and nonbenzodiazepine receptor agonist hypnotics (Z-drugs) strongly increase the risk for hip fractures and should be avoided among older adults with a fall or fracture history. We assessed BZD and Z-drugs refill patterns after discharge for hip fracture among older US adults and explored factors associated with refilling.
Methods: We conducted a retrospective cohort study of US Medicare fee-for-service beneficiaries (20% random sample) aged ≥ 66 years, hospitalized for hip fracture, and discharged home or to a skilled nursing facility.