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Oculogyric crisis (OGC) represent an unusual type of dystonic movement disorder, usually reported as an adverse event of antipsychotic drugs, with acute or tardive onset, likely due to a functional disruption of dopaminergic neurotransmission. It is seldom reported in children with aripiprazole, an atypical antipsychotic commonly used in youths. In this manuscript, we report on a case series of three pediatric patients and provide a brief narrative review of the literature, in order to increase the awareness of clinicians and to foster future research in this area.
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http://dx.doi.org/10.3390/children9010022 | DOI Listing |
Cureus
July 2025
Internal Medicine, Mediclinic Welcare Hospital, Dubai, ARE.
Ashwagandha (Withania somnifera) is a widely used herbal supplement with established adaptogenic and neuroprotective properties. Although generally considered safe, rare adverse neurological effects may occur. We present the case of a previously healthy adult male who developed acute-onset dystonia following the initiation of Ashwagandha supplementation.
View Article and Find Full Text PDFEur J Pharmacol
September 2025
Department of Pharmacy, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, 441000, Hubei, China. Electronic address:
Blonanserin, an atypical antipsychotic approved in Japan for the treatment of schizophrenia, exhibits a unique receptor affinity profile and a reportedly favorable safety profile; however, comprehensive large-scale real-world data on its adverse drug events (ADEs) remain limited. We conducted a retrospective pharmacovigilance study using the Japanese Adverse Drug Event Report (JADER) database from 2008 to 2024, focusing on ADEs where blonanserin was identified as the primary suspect drug. Safety signals were detected via disproportionality analyses employing both frequentist and Bayesian approaches and prioritized according to clinical relevance.
View Article and Find Full Text PDFPrim Care Companion CNS Disord
June 2025
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts.
Parkinsonism Relat Disord
August 2025
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. Electronic address:
Neuropediatrics
May 2025
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.