Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Solid lipid nanoparticles (SLNs) have several potential applications in the topical drug delivery. The current project aimed to prepare and characterize SLNs loaded with vitamin E for topical administration and incorporating the prepared SLNs in a cream base. Further, the permeation of prepared SLNs was studied through a synthetic membrane and the release profiles were compared with vitamin E cream. The prepared SLNs were subjected to stability studies at two different temperatures. Hot homogenization followed by dilution technique was used for the preparation of SLNs. In this project, PDMS membrane was used to mimic the skin for permeation studies. From the results of this study, it can be concluded that prepared SLNs had enhanced the permeation of vitamin E as compared to vitamin E cream.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Anticancer Phytochemical Delivery: Advances, Challenges, and Future Prospects.
Pharmaceutics
August 2025
Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia.
Phytochemicals exhibit a broad spectrum of pharmacological activities, including significant anticancer potential. However, their clinical translation is often hampered by poor aqueous solubility, low bioavailability, and chemical instability. Lipid-based nanocarriers, especially solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), have proven to be effective strategies for addressing these challenges.
View Article and Find Full Text PDFBackground: Sentinel lymph node (SLN) evaluation is central to breast cancer management. Intraoperative touch imprint cytology (TIC) and frozen section (FS) are standard, rapid techniques; however, their performance compared to the gold standard of histopathology in Sri Lanka is underreported. This study evaluates the validity of intraoperative TIC and FS in identifying SLN metastases in patients with breast cancer.
View Article and Find Full Text PDFEnhanced Photoprotection with -Loaded Solid Lipid Nanoparticles: A Novel Sunscreen Gel Formulation.
Drug Dev Ind Pharm
July 2025
School of Life Sciences, University of Sussex, Brighton, UK.
Purposes: The limitations of current sunscreens in protecting against skin cancer and aging have been acknowledged. The use of extract, rich in phenolic compounds and with strong antioxidant activity, for sunscreen applications has not been extensively studied. This study aims to develop a sunscreen gel containing (Rhubarb) root extract-loaded solid lipid nanoparticles (SLNs) and evaluate its sun protection factor (SPF) through testing.
View Article and Find Full Text PDFNanotechnology-driven Epigenetic Cancer Therapy: Precision Delivery and Sustained Release of DNA Methylation Modulators.
Yale J Biol Med
June 2025
Faculty of Pharmacy, Integral University, Lucknow, India.
Aberrant DNA methylation contributes to cancer by silencing tumor suppressor genes and facilitating tumor growth. DNA methyltransferase inhibitors (DNMTis), including 5-azacytidine (5-AZA) and decitabine (DAC), can potentially mitigate these consequences and revive gene expression. Their therapeutic effectiveness is hindered by factors like poor bioavailability, swift degradation, and unintended toxicity.
View Article and Find Full Text PDFInnovative solid lipid nanoparticle formulations for ocular therapeutics and related patents: A systematic review.
J Control Release
September 2025
University Instiute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh 160014, India. Electronic address:
Topic: This systematic review explores solid lipid nanoparticles (SLNs) as innovative drug delivery systems for ocular applications. It evaluates their ability to improve bioavailability, sustain drug release, and overcome ocular barriers in treating anterior and posterior segment disorders such as dry eye syndrome, glaucoma, infections, and retinal diseases. Comparisons with traditional delivery systems and other nanoparticle platforms are also addressed.
View Article and Find Full Text PDF