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This work depicts an electrochemical hydrogel-eutectic gallium indium alloy interface for the detection of tick-borne encephalitis (TBE) virus. This interface allows recording of nonlinear current-voltage responses, depending on the composition of the hydrogel. The current-voltage data for the machine learning model are trained by a multilayer perceptron. This model accurately recognizes the TBE antibody, antigen, and an antibody-antigen complex in mixture with interfering bovine serum albumin with 93% accuracy. Thus, this interface can be used as a convenient method for expressed viruses and pathogens detection.
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http://dx.doi.org/10.1021/acsabm.0c00954 | DOI Listing |
J Travel Med
September 2025
Virology and Pathogenesis Group, Public Health Microbiology, UK Health Security Agency, Porton Down, UK.
Our UK field investigations of tick-borne encephalitis virus were abruptly interrupted by a bed bug infestation in our short-term rental accommodation. Subsequent weeks were spent decontaminating belongings and monitoring our homes. As global bed bug infestations rise, increased awareness of prevention and control strategies is crucial for both travellers and accommodation providers.
View Article and Find Full Text PDFInt J Infect Dis
September 2025
Division of Infection and Immunity, University College London, London, United Kingdom; NIHR Biomedical Research Centre, UCL Hospitals NHS Foundation Trust, London, NW3 OPQ, United Kingdom. Electronic address:
Viruses
August 2025
Department of Microbiology and Immunology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Deer tick virus (DTV) is a Tick-Borne Orthoflavivirus endemic to the United States, transmitted to humans through bites from the deer tick, , which is also the primary vector of , the causative agent of Lyme disease. Human infection with DTV can result in acute febrile illness followed by central nervous system complications, such as encephalitis and meningoencephalitis. Currently, there are mouse models established for investigating the pathogenesis and clinical outcomes of DTV that mimic human infections, but the strains of mice utilized are refractory to infection with Here, we describe the pathogenesis and clinical outcomes of DTV infection in C3H/HeJ mice.
View Article and Find Full Text PDFViruses
July 2025
Division of Virus Research and Therapeutics, CSIR-Central Drug Research Institute, Lucknow 226031, India.
Kyasanur Forest disease virus (KFDV), a tick-borne Orthoflavivirus endemic to the Indian subcontinent, is a public health threat due to its recurrent outbreaks and expanding geographic range. This review provides a comprehensive overview of KFDV, encompassing its epidemiological trends, transmission dynamics, and ecological determinants that influence its spread. We delve into the current understanding of KFDV pathogenesis, highlighting key viral and host factors that drive infection and disease progression.
View Article and Find Full Text PDFSensors (Basel)
August 2025
Department of Medical Informatics and Artificial Intelligence, Faculty of Biomedical Engineering, Silesian University of Technology, Roosevelta 40, 41-800 Zabrze, Poland.
This article presents a deep learning approach for classifying the developmental stages (larvae, nymphs, adult females, and adult males) of ticks, the most common tick species in Europe and a major vector of tick-borne pathogens, including , , and tick-borne encephalitis virus (TBEV). Each developmental stage plays a different role in disease transmission, with nymphs considered the most epidemiologically relevant stage due to their small size and high prevalence. We developed a convolutional neural network (CNN) model trained on a dataset of microscopic tick images collected in the area of Upper Silesia, Poland.
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