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Objectives: This open, single-cohort, multicenter, prospective study investigated the efficacy of immediately provisionalized tapered conical connection implant for single-tooth restorations in the anterior and premolar regions of the maxilla after 5 years of function.
Materials And Methods: All implants were placed in healed sites and immediately provisionalized. MBLs, soft-tissue parameters, and oral-health impact profile (OHIP) were evaluated at implant insertion, 6, 12, 24, 36, and 60 months. Paired Wilcoxon signed-rank tests and Kaplan-Meier survival analysis was used for statistical and implant survival/success analyses, respectively.
Results: Seventy-seven patients (81 implants) completed the 5-year follow-up. The 5-year cumulative survival and success rates were 97.8%, and the mean MBL change from implant insertion to 5 years was - 0.80 ± 1.13 mm. Optimal papilla index scores were observed at 90.1% of sites at 5 years compared with 32.8% of sites at insertion. Pink esthetic score, modified bleeding and plaque indices, and OHIP showed statistically significant improvement at the 5-year follow-up.
Conclusions: Immediately provisionalized tapered conical connection implants promote marginal bone stability and excellent esthetic outcomes after 5 years of function.
Clinical Relevance: This treatment is a viable option for patients requiring immediately provisionalized single-tooth restorations in the esthetic zone and shows favorable long-term clinical outcomes, including marginal bone stability and excellent esthetics.
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http://dx.doi.org/10.1007/s00784-021-04328-2 | DOI Listing |
Curr Biol
September 2025
Department of Integrative Biology, University of South Florida, Tampa, FL 33620, USA.
Rapid movements in animals depend on efficient energy transfer to overcome inertia. Among vertebrates, dense tissue and limited elastic storage are thought to impose profound constraints on power output, making extreme ballistic performance noteworthy. Here, we show that chameleons (Chamaeleonidae) and some lungless salamanders (Plethodontidae) have independently converged on a shared biomechanical solution: a sliding-based linear actuator that launches the tongue via muscular squeezing of a tapered skeletal rod.
View Article and Find Full Text PDFBMJ Case Rep
August 2025
Critical Care Medicine, Yashoda Group of Hospitals, Hyderabad, India.
New-onset refractory status epilepticus (NORSE) presents a significant challenge, particularly in the absence of a clear aetiology and resistance to conventional treatments. Managing NORSE during pregnancy is even more complex due to the lack of established guidelines and concerns over the teratogenicity of available antiepileptic drugs (AEDs).A previously healthy pregnant woman with no history of seizures developed refractory NORSE, resistant to multiple AEDs and anaesthetic infusions.
View Article and Find Full Text PDFCell Rep Methods
August 2025
UPMC Hillman Cancer Center, University of Pittsburgh, 5115 Centre Avenue, Pittsburgh, PA 15232, USA; Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15260, USA; Department of Computational and Systems Biology, University of Pi
This paper reports a 3D-printed plug as a meso-scale interface solution that minimizes sample loss and enhances cell usage efficiency, seamlessly connecting microfluidic systems to conventional well plates. The plug concentrates cells near the region of interest for chemotaxis, reducing cell number requirements and featuring tapered structures for efficient manual or robotic liquid handling. Comprehensive testing showed that the plug increased cell usage efficiency in single-cell migration assays by 8-fold, maintaining accuracy and sensitivity.
View Article and Find Full Text PDFCurr Drug Saf
June 2025
Department of Geriatric Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Introduction: DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) is a rare adverse drug reaction characterized by cutaneous and systemic manifestations, with a mortality rate of up to 10%. In this study, we describe the case of a 77-year-old man who developed DRESS syndrome with cold agglutination.
Case Presentation: A 77-year-old man prescribed phenytoin and carbamazepine for suspected cranial neuralgia after a tooth extraction developed high-grade fever and hemorrhagic crusting on the upper and lower lips and oral mucosa, morbilliform rashes over the chest, abdomen, and back along with facial edema, all occurring over 2 weeks.
JMA J
April 2025
Department of Rheumatology, Tohoku University Hospital, Sendai, Japan.
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive dermatomyositis (DM) is characterized by mild or absent muscle involvement and unique skin lesions such as cutaneous ulceration and palmar papules, commonly associated with rapidly progressive interstitial lung disease (RP-ILD), causing fatal outcomes. Spontaneous intramuscular hemorrhage (SIH) is an extremely rare but severe complication that remains under-recognized in DM. Here, we report a case of multiple SIH in a 72-year-old Japanese woman with anti-MDA5 antibody-positive DM and RP-ILD.
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