Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aims: The aim of this retrospective study was to investigate SUVs variability with respect to lesion size, administered dose, and reconstruction algorithm.
Background: SUV and SUV are influenced by technical factors as count statistics and reconstruction algorithms.
Objective: To fulfill the aim, we evaluated the SUVs variability with respect to lesion size, administered dose, and reconstruction algorithm (ordered - subset expectation imization plus point spread function option - OSEM+PSF, regularized Bayesian Penalized Likelihood - BPL) in a 5 - rings BGO PET/CT scanner.
Methods: Discovery IQ scanner (GE Healthcare, Milwaukee, Wisconsin, US) was used for list mode acquisition of 25 FDG patients, 12 injected with 3.7 MBq/kg (Standard Dose protocol - SD) and 13 injected with 1.8 MBq/kg (Low Dose protocol - LD). Each acquisition was reconstructed at different time/FOV with both OSEM+PSF algorithm and BPL using seven different beta factors. SUVs were calculated in 70 lesions and analysed in function of time/FOV and Beta. Image quality was evaluated as a coefficient of variation of the liver (CV - liver).
Results: SUVs were not considerably affected by time/FOV. However, SUVs were influenced by beta: differences were higher in small lesions (37% for SUV, 15% for SUV) compared to larger ones (14% and 6%). CV - liver ranged from 6% with Beta-500 (LD and SD) to 13% with Beta- 200 (LD). CV - liver of BPL with Beta-350 (optimized for clinical practice in our institution) in LD was lower than CV - liver of OSEM+PSF in SD.
Conclusion: When a high sensitivity 5 - rings BGO PET/CT scanner is used with the same reconstruction algorithm, quantification by means of SUV and SUV is a robust standard compared to the activity and scan duration. However, both SUVs and image quality are influenced by reconstruction algorithms and the related parameters should be considered to obtain the best compromise between detectability, quantification, and noise.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2174/1874471015666220107100200 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Evaluation of a digital bismuth germanium oxide PET/CT system according to the Japanese brain tumor phantom test for F-fluciclovine imaging.
Phys Eng Sci Med
July 2025
Department of Nuclear Medicine, The Cancer Institute Hospital of Japanese Foundation for Cancer Research, 3-8-31 Ariake, Koto-ku, Tokyo, 135-8550, Japan.
The Omni Legend (GE Healthcare), equipped with a digital bismuth germanium oxide PET/CT system, has been recently developed. However, the performance of the Omni Legend without a time-of-flight (TOF) system for F-fluciclovine imaging is still unclear. Therefore, this study evaluated the image quality of the Omni Legend according to the Japanese brain tumor phantom test (JBT) criteria, and assessed its potential use for F-fluciclovine imaging.
View Article and Find Full Text PDFUltra-low dose imaging in a standard axial field-of-view PET.
EJNMMI Rep
July 2025
Department of Radiology and Nuclear Medicine, Luzerner Kantonsspital, University Teaching and Research Hospital, University of Lucerne, Lucerne, Switzerland.
Though ultra-low dose (ULD) imaging offers notable benefits, its widespread clinical adoption faces challenges. Long-axial field-of-view (LAFOV) PET/CT systems are expensive and scarce, while artificial intelligence (AI) shows great potential but remains largely limited to specific systems and is not yet widely used in clinical practice. However, integrating AI techniques and technological advancements into ULD imaging is helping bridge the gap between standard axial field-of-view (SAFOV) and LAFOV PET/CT systems.
View Article and Find Full Text PDFMeasurement accuracy and practicality of O-gas PET using a high-sensitivity whole-body PET/CT scanner.
Ann Nucl Med
June 2025
Department of Molecular Imaging Research, Kobe City Medical Center General Hospital, 2-1-1, Minatojimaminamimachi, Chuo-Ku, Kobe, Japan.
Objective: O-gas PET allows for the quantitative measurement of cerebral circulation and metabolism. However, the administration of high radioactivity doses raises concerns about count losses, particularly when using high-sensitivity whole-body PET/CT scanners equipped with BGO detectors. Therefore, optimizing the administration dose is crucial.
View Article and Find Full Text PDFEffects of a deep learning-based image quality enhancement method on a digital-BGO PET/CT system for F-FDG whole-body examination.
EJNMMI Phys
March 2025
Center of Radiology and Diagnostic Imaging, Aizawa Hospital, 2-5-1 Honjo, Matsumoto-Shi, Nagano, 390-8510, Japan.
Background: The digital-BGO PET/CT system, Omni Legend 32, incorporates modified block sequential regularized expectation maximization (BSREM) image reconstruction and a deep learning-based time-of-flight (TOF)-like image quality enhancement process called Precision DL (PDL). The present study aimed to define the fundamental characteristics of PDL using phantom and clinical images.
Methods: A NEMA IEC body phantom was scanned using the Omni Legend 32 PET/CT system.
Deep learning-based time-of-flight (ToF) enhancement of non-ToF PET scans for different radiotracers.
Eur J Nucl Med Mol Imaging
July 2025
Department of Medical Physics and Clinical Engineering, Oxford University Hospitals NHS FT, Oxford, UK.
Aim: To evaluate a deep learning-based time-of-flight (DLToF) model trained to enhance the image quality of non-ToF PET images for different tracers, reconstructed using BSREM algorithm, towards ToF images.
Methods: A 3D residual U-NET model was trained using 8 different tracers (FDG: 75% and non-FDG: 25%) from 11 sites from US, Europe and Asia. A total of 309 training and 33 validation datasets scanned on GE Discovery MI (DMI) ToF scanners were used for development of DLToF models of three strengths: low (L), medium (M) and high (H).