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Importance: People with bilateral vestibulopathy experience severe balance and mobility issues. Fear and anxiety are associated with reduced activity, which can further affect balance and fall risk. Understanding and intervening on falls in this population is essential. The aims of this narrative review are to provide an overview of the current knowledge and applied methods on fall incidence, causes, and injuries in bilateral vestibulopathy.
Observations: Eleven articles reporting falls incidence in people with bilateral vestibulopathy were deemed eligible, including 3 prospective and 8 retrospective studies, with a total of 359 participants, of whom 149 (42%) fell during the assessed period. When reported, the most common perceived causes of falls were loss of balance, darkness, and uneven ground. Information on sustained injuries was limited, with bruises and scrapes being the most common, and only 4 fractures were reported. As most studies included falls as a secondary, descriptive outcome measure, fall data obtained using best practice guidelines were lacking. Only 6 studies reported their definition of a fall, of which 2 studies explicitly reported the way participants were asked about their fall status. Only 3 studies performed a prospective daily fall assessment using monthly fall diaries (a recommended practice), whereas the remaining studies retrospectively collected fall-related data through questionnaires or interviews. While most studies reported the number of people who did and did not fall, the number of total falls in individual studies was lacking.
Conclusions And Relevance: The findings from this review suggest that falls in people with bilateral vestibulopathy are common but remain an understudied consequence of the disease. Larger prospective studies that follow best practice guidelines for fall data collection with the aim of obtaining and reporting fall data are required to improve current fall risk assessments and interventions in bilateral vestibulopathy.
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http://dx.doi.org/10.1001/jamaoto.2021.3673 | DOI Listing |
J Neurol
September 2025
Department of Nutrition and Movement Sciences, NUTRIM Institute of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Objectives: Dynamic visual acuity (DVA) can be assessed on a treadmill while walking at different speeds and is used to assess people with bilateral vestibulopathy (BVP). However, the effects and interactions of age, BVP, and walking speed on DVA loss and assessment dropout are unclear. Our objective was to investigate the effects of BVP, age, and walking speed on DVA loss and assessment dropout in participants with BVP and healthy age-sex-matched participants.
View Article and Find Full Text PDFEur J Neurol
August 2025
SENSE Research Unit, Queen Square Institute of Neurology, London, UK.
Background: Persistent Postural-Perceptual Dizziness (PPPD) is a prevalent functional neuro-otologic disorder characterised by non-spinning vertigo, perceived instability and visual motion sensitivity. Diagnostic criteria currently prioritise physical symptoms; although psychological factors are clinically linked to symptom onset and maintenance. This study investigates psychological factors in vestibular disorders by comparing PPPD patients with healthy controls, and exploratorily, with Bilateral Vestibulopathy (BVP) patients, identifying differentiating constructs and potential treatment targets.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
August 2025
Department of Otorhinolaryngology and Head and Neck Surgery, Division of Vestibular Disorders, Maastricht University Medical Center, Maastricht, The Netherlands.
Purpose: Vestibular implantation holds considerable potential as a therapeutic strategy for individuals with vestibular loss. A correct position of the stimulation electrodes is essential for effective implant functionality. For vestibular implants targeting the semi-circular canals, Vestibulo-Ocular Reflex testing (VOR testing) is used to evaluate functionality postoperatively.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
September 2025
Department of Otorhinolaryngology-Head and Neck Surgery, Mental Health and Neuroscience (MHeNS), Faculty of Health Medicine and Life Sciences, Maastricht University Medical Center, Maastricht, the Netherlands; Department of Otolaryngology-Head and Neck Surgery, Antwerp University Hospital, Antwerp,
Background: Vestibular hypofunction in children can lead to frequent falls and delayed motor development. Especially children with bilateral vestibular hypofunction (BVH) are most at risk for developing symptoms. These children might benefit from future therapies, like vestibular implants, to restore their vestibular system.
View Article and Find Full Text PDFBull Cancer
August 2025
Department of Otorhinolaryngology and Head and Neck Surgery, CHU de Rouen, 76000 Rouen, France.
Context: Therapeutics used in cancer treatment can cause vestibular ototoxicity, which is particularly challenging to detect due to the frequent occurrence of nausea and vomiting in patients experiencing significant fatigue and stress. An appropriate diagnosis enables optimal symptom correction, reduces the risk of falls, and improves quality of life.
Materials And Methods: Following a concise overview of the anatomy, physiology, and principles of vestibular exploration, a narrative review of the primary vestibulopathies encountered in cancer patients is conducted.