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http://dx.doi.org/10.1183/13993003.02857-2021 | DOI Listing |
Brain Sci
July 2025
Program in Physical Therapy, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA.
Background/objectives: Huntington's disease (HD) is a neurodegenerative disorder involving the basal ganglia and is characterized by psychiatric, cognitive, and movement dysfunction, including gait and balance impairment. Given the limited efficacy of pharmacological treatments for HD motor symptoms, nonpharmacological approaches like rhythmic auditory stimulation are being explored. This study aims to describe walking performance in people with HD during rhythmic auditory stimulation using external musical cues and internal singing cues.
View Article and Find Full Text PDFClin Park Relat Disord
August 2025
School of Medicine and Allied Health Sciences, University of The Gambia, Banjul, the Gambia.
Parkinson's disease (PD) is a complex neurodegenerative disorder requiring multidimensional treatment approaches. Recent breakthroughs in precision medicine and growing evidence for music therapy efficacy present new opportunities for comprehensive PD management that addresses both biological mechanisms and quality of life outcomes This mini review evaluates the current state of precision medicine and music therapy interventions for PD, with three primary aims: (1) to synthesize evidence for genetic-based treatments and music-based interventions, (2) to identify potential synergies between these approaches, and (3) to highlight critical implementation challenges in clinical practice. Our analysis revealed that precision medicine approaches, including GBA1-targeted venglustat and LRRK2 kinase inhibitors, show significant promise in clinical trials when guided by genetic profiling.
View Article and Find Full Text PDFInt J Environ Res Public Health
June 2025
Freiburg Institute for Musicians' Medicine, University of Music Freiburg, Medical Center and Faculty of Medicine-University of Freiburg, Freiburg Centre for Music Research and Teaching, Elsässerstr. 4 d, 79110 Freiburg, Germany.
Voice disorders occur frequently in schoolteachers. The aim of the present cross-sectional study involving 124 German teachers was to investigate whether singing, voice training, and high self-efficacy are protective factors for vocal health. Furthermore, vocal self-concept was examined as a potential mediator explaining this relationship.
View Article and Find Full Text PDFJAMA Neurol
September 2025
ENT Institute and Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, China.
Importance: OTOF gene therapy (GT) has been shown to improve hearing and speech. The efficacy of GT remains to be compared against cochlear implantation (CI), the current gold standard for congenital deafness.
Objective: To evaluate treatment outcomes in auditory and speech perception between patients with congenital deafness treated with GT, CI, or both.
Sensors (Basel)
June 2025
College of Computer and Information Engineering (College of Artificial Intelligence), Nanjing Tech University, Nanjing 211816, China.
Although Singing Voice Synthesis (SVS) has revolutionized audio content creation, global linguistic diversity remains challenging. Current SVS research shows scant exploration of cross-lingual generalization, as fragmented, language-specific phoneme encodings (e.g.
View Article and Find Full Text PDF