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The paper presents a method for checking the geometry of stamped car body parts using a 3D optical measurement system. The analysis focuses on the first forming operation due to the deformation and material flow associated with stall thresholds. An essential element of the analysis is determining the actual gap occurring between the forming surfaces based on the die and punch geometry used in the first stamping operation. The geometry of car body elements at individual production stages was analyzed using an optical laser scanner. The control carried out in this way allowed one to correctly position the tools (punch and die), thus introducing the correction of technological parameters, having a fundamental influence on the specific features of the final product. This type of approach has not been used before to calibrate the technological line and setting of shaping tools. The influence of the manufactured product geometry in intermediate operations on the final geometry features was not investigated.
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http://dx.doi.org/10.3390/ma14247608 | DOI Listing |
PLoS One
September 2025
Department of Hygiene, Kawasaki Medical School, Kurashiki, Japan.
T-cell therapies have proven to be a promising treatment option for cancer patients in recent years, especially in the case of chimeric antigen receptor (CAR)-T cell therapy. However, the therapy is associated with insufficient activation of T cells or poor persistence in the patient's body, which leads to incomplete elimination of cancer cells, recurrence, and genotoxicity. By extracting the splice element of PD-1 pre-mRNA using biology based on CRISPR/dCas13 in this study, our ultimate goal is to overcome the above-mentioned challenges in the future.
View Article and Find Full Text PDFTher Drug Monit
September 2025
Laboratory of Clinical Pharmacology and Pharmacogenetics, Department of Medical Sciences, University of Turin, Amedeo di Savoia Hospital, Turin, Italy; and.
Background: Tuberculosis (TB) treatment relies on a prolonged first-line antibiotic regimen, including isoniazid, rifampicin (RF), ethambutol (EMB), and pyrazinamide.Pharmacogenetics plays a crucial role in optimizing TB treatment by addressing individual variability in drug metabolism and responses. Genetic polymorphisms can significantly affect pharmacokinetics and therapeutic outcomes.
View Article and Find Full Text PDFMaterials (Basel)
August 2025
Department of Vehicle and Machine Mechatronics, Faculty of Mechanical Engineering, Opole University of Technology, Prószkowska Street 76, 45-758 Opole, Poland.
Passenger cars have unibody constructions, which means that their collision damage often involves key structural components. Successful repair requires the selection of appropriate technology and adherence to quality standards, which directly affects the safety of the vehicle's continued operation. A commonly used method is a system of replacing damaged components with new ones, while repair by molding and forming is also possible-provided the original structural features are preserved.
View Article and Find Full Text PDFExp Physiol
August 2025
Department of Medicine, University of Udine, Udine, Italy.
The study investigated whether bicycle compared with car commuting, over relatively small distances, has positive effects on physiological variables, cardiometabolic fitness and CO output in the atmosphere. Bike Commuters (11 M, 15 F; age [median value (interquartile range)] 51.5 (38.
View Article and Find Full Text PDFFront Microbiol
August 2025
Department of Veterinary Pathology, West Bengal University of Animal and Fishery Sciences (W.B.U.A.F.S), Kolkata, India.
Antibiotic growth promoters (AGPs) are widely used as feed additives to enhance the immunity, and productivity in the poultry industries. But over usage of AGPs has led to multi drug-resistance among pathogens. Nonspecific immunomodulators like probiotics have emerged as competent replacements of AGPs.
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