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Background And Objective: Paranoia is an important psychiatric symptom with a remarkable effect on daily life. Virtual reality (VR)-based treatments are influential and safe for patients with paranoia. This study aimed to evaluate the effectiveness, and define the clinical and technical characteristics of available VR strategies for the treatment of patients with paranoia.
Materials And Methods: Studies published up to 25/11/2021 reporting VR-based interventions for the treatment of patients with paranoia were reviewed in five databases, including PubMed, Embase, Web of Science, PsycINFO, and Scopus.
Results: Out of 302 initial search results, eight were included in the present study based on the inclusion criteria. Six studies were randomized clinical trials with the interventions in the experimental group being based on VR, compared to routine interventions as controls. Two were before-after studies. The most commonly used hardware and software were head-mounted display and Unity3D, respectively. Interventions had a range of 1-16 sessions with follow-up durations of 0-6 months. All investigations showed positive results in the main target, including improved social participation, reduced level of anxiety, as well as diminished suspicious ideas and paranoid symptoms.
Conclusions: Our findings demonstrated that VR-based interventions are effective treatments. Although the use of VR technology is limited for a variety of reasons, such as cost, it improves symptoms in patients with paranoia.
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http://dx.doi.org/10.1016/j.psychres.2021.114338 | DOI Listing |
Psychodyn Psychiatry
September 2025
Private practice, Tampa, Florida; Assistant Professor of Psychiatry, University of Central Florida College of Medicine; Adjunct Assistant Professor of Psychiatry, Tufts University School of Medicine.
Paleologic thinking, a prelogical mode of reasoning described by Silvano Arieti, is characterized by emotion-driven, retrospective reasoning and has been observed in severe mental illnesses such as schizophrenia. The author explores its relevance to borderline personality disorder, an area that has been historically understudied. Patients with borderline personality disorder often regress into paleologic modes of thought during interpersonal distress, resulting in illogical conclusions driven by feelings rather than evidence.
View Article and Find Full Text PDFNeurohospitalist
August 2025
Department of Neurocritical Care, University of Missouri Columbia School of Medicine, Columbia, MO, USA.
Baclofen, a GABA agonist, is used for the management of spasticity. Intrathecal route is indicated in cases of severe spasticity associated with spinal cord injury. Baclofen withdrawal symptoms can happen after IT pump removal which can present as anxiety, paranoia, psychosis, seizures, hallucinations, severe spasticity and dyskinesia.
View Article and Find Full Text PDFJ Affect Disord
August 2025
Department of Counseling Psychology, Hannam University, Daejeon, Republic of Korea. Electronic address:
Depressive disorder is a prevalent mental illness that exhibits distinct symptom profiles across life stages. This study examined age-related differences in core psychopathological symptoms and network structures among individuals with depressive disorders, using the Minnesota Multiphasic Personality Inventory-2 (MMPI-2). A total of 524 patients aged 18-65 years were stratified into four age groups: late adolescence (18-25), early adulthood (26-35), mid-adulthood (36-50), and late mid-adulthood (51-65).
View Article and Find Full Text PDFBehav Cogn Psychother
August 2025
Department of Experimental Psychology, University of Oxford, Oxford, UK.
Background: Defence behaviours - actions carried out to reduce perceived threat - are an important maintenance factor for persecutory delusions. Avoidance of feared situations and subtle in-situation behaviours reduce opportunities for new learning and are erroneously credited for the non-occurrence of harm; hence inaccurate fears are maintained. In contrast, exposure to feared situations whilst dropping defence behaviours - a key technique of cognitive therapy for paranoia - allows the discovery of new information concerning safety, thereby reducing persecutory delusions.
View Article and Find Full Text PDFJ Behav Ther Exp Psychiatry
December 2025
Department of Health Information Technology, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address:
Introduction: patients with schizophrenia have deficits in social cognition and functioning. Virtual reality is a 3D real-world simulation created by a computer. Virtual reality-based cognitive behavioral therapy might increase effectiveness and acceptability of treatment for these patients.
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