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http://dx.doi.org/10.1093/jat/bkab120 | DOI Listing |
Forensic Toxicol
July 2025
Department of Forensic Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, Japan.
Purpose: This study aims to detail the identification, confirmation, and quantitation of lemborexant from clinical and postmortem specimens using a validated LC-MS/MS method. Additionally, it investigates the tissue distribution of lemborexant in several postmortem cases.
Methods: Lemborexant was isolated from the plasma of hospital patients or the postmortem specimens of forensic autopsy cases.
J Anal Toxicol
July 2025
Miami-Dade County Medical Examiner Department, Toxicology Laboratory, 1851 NW 10th Avenue, Miami, FL, 33136, USA.
In postmortem forensic toxicology, the accuracy and reliability of toxicological results are critical to the medicolegal death investigation process. ANSI/ASB Standard 056: Standard for Evaluation of Measurement Uncertainty in Forensic Toxicology establishes the minimum requirements for evaluating measurement uncertainty (MU) in quantitative methods utilized in forensic toxicology. Accurate evaluation of MU increases confidence in results, supports scientific rigor, enables inter-laboratory comparability, and ensures legal defensibility.
View Article and Find Full Text PDFJ Anal Toxicol
June 2025
9-Delta Analytical LLC, 4365 E. Lowell Street, Suit E, Ontario, CA, 91767.
Oral fluid is considered a favorable matrix for the identification of drug intake mainly because of its simple, observed, non-invasive collection. Fentanyl and fentanyl analog use, misuse, overdose, and deaths are currently occurring at an alarming rate in the USA. The law enforcement community, the Food and Drug Administration (FDA) and the Centers for Disease Control (CDC) are all keenly aware of the urgency in addressing an unmet public health need to identify opioid overdose in individuals as rapidly as possible.
View Article and Find Full Text PDFJ Anal Toxicol
June 2025
Office of the Chief Medical Examiner, 7007-116 Street NW, Edmonton, Alberta, Canada.
The purpose of this study was to develop and validate an analytical method to chromatographically separate, identify and quantify ortho-methylfentanyl (o-methylfentanyl) in postmortem blood. A combination of simple protein precipitation with liquid chromatography-tandem mass spectrometry (LC-MS/MS) was utilized to facilitate chromatographic separation of similar fentanyl analogs, including both meta (m-) and para (p-) methylfentanyl. The analytical range was 1 to 200 ng/mL; the method was validated in accordance with ANSI/ASB Standard 036.
View Article and Find Full Text PDF