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Motor vehicle crashes are a leading cause of police injuries and deaths in line of duty. These crashes have been mainly attributed to the use of in-vehicle technologies while driving. Police officers receive extensive training on driving skills; however, limited training is provided on the use of in-vehicle technologies. Variable priority training (VPT) is a computer-based training that has shown promising results in improving multi-tasking performance. Eighteen police officers participated in a driving simulation study to assess the effect of VPT on officers' performance and workload. Findings suggested that although VPT was effective in improving officers' performance in dual and multi-task simulations across the training sessions, this effect was not generally transferred to driving. However, the VPT might be effective for training of high-demand situations involving pursuit driving and multiple secondary tasks. The findings can be beneficial for police agencies to improve training protocols. A driving simulation study was conducted to assess the effect of a computer-based training approach on police officers' driving performance and cognitive workload. The findings suggested that the proposed training approach might be effective for training of high-demand situations involving pursuit driving and multi-tasking.
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http://dx.doi.org/10.1080/00140139.2021.2013550 | DOI Listing |
Driven by eutrophication and global warming, the occurrence and frequency of harmful cyanobacteria blooms (CyanoHABs) are increasing worldwide, posing a serious threat to human health and biodiversity. Early warning enables precautional control measures of CyanoHABs within water bodies and in water works, and it becomes operational with high frequency in situ data (HFISD) of water quality and forecasting models by machine learning (ML). However, the acceptance of early warning systems by end-users relies significantly on the interpretability and generalizability of underlying models, and their operability.
View Article and Find Full Text PDFBiomaterials
September 2025
Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address:
The stimulator of interferon genes (STING) pathway represents a promising target in cancer immunotherapy. However, the clinical translation of cyclic dinucleotide (CDN)-based STING agonists remains hindered by insufficient formation of functional CDN-STING complexes. This critical bottleneck arises from two interdependent barriers: inefficient cytosolic CDN delivery and tumor-specific STING silencing via DNA methyltransferase-mediated promoter hypermethylation.
View Article and Find Full Text PDFAm J Emerg Med
September 2025
Department of Surgical Education, Orlando Regional Medical Center, Orlando, FL, USA; Department of Surgery, Division of Trauma and Surgical Critical Care, Orlando Regional Medical Center, Orlando, FL, USA. Electronic address:
Background: There is conflicting literature regarding mortality outcomes associated with REBOA usage in patients with severe thoracic or abdominal trauma. Our study aims to assess the benefits and negative implications of REBOA use in adult trauma patients in hemorrhagic shock with severe thoracic or abdominal injuries.
Methods: This retrospective cohort analysis utilized the American College of Surgeons Trauma Quality Improvement Program Participant Use File (ACS-TQIP-PUF) database from 2017 to 2023 to evaluate adult patients with severe isolated thoracic or abdominal trauma undergoing REBOA placement.
Anim Reprod Sci
September 2025
Department of Biomedical & Clinical Sciences (BKV), BKH/Obstetrics & Gynecology, Faculty of Medicine and Health Sciences, Linköping University, Linköping SE-58185, Sweden.
Embryo transfer (ET) is a valuable reproductive technology in pigs, albeit its efficiency remains significantly lower than that of natural mating or artificial insemination (AI), owing to high embryonic death rates. Critical for embryo survival and pregnancy success is the placenta, which supports conceptus development through nutrient exchange, hormone production, and immune modulation. Alterations in placental development and function may therefore underlie the reduced efficiency of ET.
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