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http://dx.doi.org/10.1016/j.jpsychores.2021.110684 | DOI Listing |
Lancet Gastroenterol Hepatol
August 2025
Department of Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Psychogastroenterology encompasses both basic mechanistic research, which identifies psychological mechanisms (eg, fear-learning) that contribute to disorders of gut-brain interaction (DGBIs), and clinical applied research, which evaluates the efficacy of gut-brain behavioural therapies in DGBIs. However, progress in the field is hindered by inadequate communication between these areas, such that mechanistic processes are rarely translated into clinical targets, and interventions are developed with an incomplete understanding of the potential mechanisms by which they work or for whom they work. To bridge this translational gap, we propose the psychobiological model of DGBIs-an integrated and testable model that illustrates how psychological mechanisms central to DGBIs interact with each other and with biological processes along the gut-brain axis.
View Article and Find Full Text PDFGastroenterol Clin North Am
September 2025
Department of Pediatrics, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Memphis, TN, USA. Electronic address:
Disorders of gut brain interaction (DGBI) are common disorders that can have a large effect on quality of life of children and their caregivers. These disorders are best treated using a biopsychosocial approach that incorporates screening for biological and environmental triggers and implementing treatments that target the gut-brain axis. These treatments, best offered by a psychogastroenterology specialist, can offer significant improvement to symptoms for many gastrointestinal diseases.
View Article and Find Full Text PDFExpert Rev Gastroenterol Hepatol
June 2025
Department of Gastroenterology, Pomeranian Medical University, Szczecin, Poland.
Introduction: Functional dyspepsia (FD) and irritable bowel syndrome (IBS) are the most prevalent disorders of gut-brain interaction (DGBI), frequently overlapping and associated with complex pathophysiological mechanisms. Increasing evidence implicates gut microbiota alterations in driving symptoms via immune activation, altered motility, gut vascular barrier and gut-brain axis disruption.
Areas Covered: This review explores the role of gut microbiota in FD and IBS pathogenesis and symptomatology.
Neurogastroenterol Motil
April 2025
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.
Introduction: Cognitive behavioral therapy (CBT) and gut-directed hypnosis (GDH) are the two most widely used brain-gut behavior therapies (BGBT) for irritable bowel syndrome (IBS), but nearly all that is known about their clinical effects comes from formal trials rather than clinical practice. We aimed to collect data from BGBT practitioners on their use and perception of these treatments, including positive and negative effects in their most recently treated patients.
Methods: Rome Foundation Psychogastroenterology section listserv members and other clinicians known to regularly treat IBS with CBT or GDH (166 total) were invited via email to participate in a de-identified Internet survey.
Transl Gastroenterol Hepatol
January 2025
The Rome Foundation Research Institute, Raleigh, NC, USA.