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Background: Malalignment in total knee arthroplasty has been associated with poor implant longevity and clinical outcomes. The aim of this study was to investigate the accuracy of accelerometer-based navigation in restoring the mechanical axis.
Methods: 106 primary total knee arthroplasties performed during February 2016 to September 2017 at a tertiary care centre in India were enrolled in this observational study. We noted the intra-op tourniquet time. Two separate blinded observers measured the preoperative mechanical axis and the post operative radiological results (mechanical axis, coronal and sagittal alignment of femoral and tibial components) and the mean value was taken as final data. Interclass correlation was done to look for variability between the two observers.
Results: The mean pre operative mechanical axis was 13.74 ± 10.44. The mean tourniquet time was 53.14 ± 7.42 min 91.5% (96/106) knees were within ±3° of neutral mechanical axis with a mean of 1.00° ± 2.68°. The femoral and tibial components with coronal alignment within ±3° perpendicular to the mechanical axis were 93.39% (99/106) and 89.62% (95/106) respectively. In the sagittal plane 89.62% of the femoral components and 87.73% of the tibial components were within ±3° perpendicular to the axis of tibia.
Conclusion: The Accelerometer based portable navigation system effectively reduces the coronal and sagittal alignment outliers in total knee arthroplasty and has no role in rotational alignment of components.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8605332 | PMC |
http://dx.doi.org/10.1016/j.jcot.2021.101689 | DOI Listing |
Background And Aims: Trait-based approaches have advanced our understanding of plant strategies, yet they often focus on leaf-level traits, overlooking the functional roles of stem anatomy and twig characteristics. We investigated intraspecific trait variation in Salix flabellaris, an alpine dwarf shrub, along climatic gradients in the Himalayas. Our goal was to identify distinct axes of trait variation related to stem, twig, and leaf traits, assess their environmental drivers, and evaluate population-specific growth responses to recent climate change.
View Article and Find Full Text PDFJB JS Open Access
September 2025
Division of Orthopedic Surgery, Department of Regenerative and Transplant Medicine, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan.
Background: Lower extremity alignment in knee osteoarthritis (OA) is conventionally assessed using standing radiographs. However, symptoms often manifest during gait. Understanding dynamic alignment during gait may help characterize disease progression and inform treatment strategies.
View Article and Find Full Text PDFJ Arthroplasty
September 2025
Department of Orthopedic Surgery, Korea University College of Medicine, Ansan Hospital, Ansan-si, Gyeonggi-do, South Korea. Electronic address:
Background: Lower-limb alignment should be accurately assessed to achieve favorable outcomes after total knee arthroplasty (TKA). Compared to conventional alignment methods, the recently adopted hip-to-calcaneus (HTC) axis better reflects actual weight-bearing alignment by including hindfoot alignment. However, whether discrepancies between two mechanical alignments vary according to ankle osteoarthritis (OA) and whether such discrepancies are clinically meaningful remains unclear.
View Article and Find Full Text PDFPLoS Comput Biol
September 2025
Mathematical and Statistical Methods (Biometris), Wageningen University, Wageningen, The Netherlands.
Many plant cell functions, including cell morphogenesis and anisotropic growth, rely on the self-organisation of cortical microtubules into aligned arrays with the correct orientation. An important ongoing debate is how cell geometry, wall mechanical stresses, and other internal and external cues are integrated to determine the orientation of the cortical array. Here, we demonstrate that microtubule-based nucleation can markedly shift the balance between these often competing directional cues.
View Article and Find Full Text PDFJ Vis Exp
August 2025
Laboratory of Regenerative Medicine in Sports Science, School of Physical Education and Sports Science, South China Normal University; Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences;
Post-traumatic osteoarthritis (PTOA) is a degenerative joint disease triggered by trauma or intense mechanical stress, leading to joint cartilage degeneration and functional impairment. Prostaglandin E2 (PGE2) contributes significantly to cartilage degradation following mechanical injury by activating its receptor, Prostaglandin E receptor 4 (EP4), on chondrocyte membranes. The homeostasis of articular cartilage primarily relies on the dynamic balance between cartilage degradation and repair, a process finely regulated by chondrocytes.
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