Allergic Diseases: A Comprehensive Review on Risk Factors, Immunological Mechanisms, Link with COVID-19, Potential Treatments, and Role of Allergen Bioinformatics.

Int J Environ Res Public Health

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.

Published: November 2021


Article Synopsis

  • Allergic diseases are a major global health challenge, with rising prevalence linked to both genetic and environmental factors.
  • Emerging research indicates that elements like the immune system, microbiota, and certain pathogens are involved in allergy development.
  • Allergen bioinformatics plays a crucial role by providing computational tools and data resources for understanding allergies, while also pointing to future research directions in allergology.

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Article Abstract

The prevalence of allergic diseases is regarded as one of the key challenges in health worldwide. Although the precise mechanisms underlying this rapid increase in prevalence are unknown, emerging evidence suggests that genetic and environmental factors play a significant role. The immune system, microbiota, viruses, and bacteria have all been linked to the onset of allergy disorders in recent years. Avoiding allergen exposure is the best treatment option; however, steroids, antihistamines, and other symptom-relieving drugs are also used. Allergen bioinformatics encompasses both computational tools/methods and allergen-related data resources for managing, archiving, and analyzing allergological data. This study highlights allergy-promoting mechanisms, algorithms, and concepts in allergen bioinformatics, as well as major areas for future research in the field of allergology.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8622387PMC
http://dx.doi.org/10.3390/ijerph182212105DOI Listing

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