Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Purpose: This study presents patient-specific quality assurance (QA) results from the first 395 clinical cases for the new helical TomoTherapy® platform (Radixact) coupled with dedicated Precision TPS.
Methods: The passing rate of the Gamma Index (GP%) of 395 helical QA of patient-specific tomotherapy, acquired with ArcCHECK, is presented, analysed and correlated to various parameters of the plan. Following TG-218 recommendations, the clinic specific action limit (AL) and tolerance limit (TL) were calculated for our clinic and monitored during the analysed period.
Results: The mean values (± 1 standard deviation) of GP% (3%/2 mm) (both global and local normalization) are: 97.6% and 90.9%, respectively. The proposed AL and TL, after a period of two years' process monitoring are 89.4% and 91.1% respectively.
Conclusions: The phantom measurements closely match the planned dose distributions, demonstrating that the calculation accuracy of the new Precision TPS and the delivery accuracy of the Radixact unit are adequate, with respect to international guidelines and reports. Furthermore, a first correlation with the planning parameters was made. Action and tolerance limits have been set for the new Radixact Linac.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8607724 | PMC |
| http://dx.doi.org/10.1186/s13014-021-01952-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multi-Center Health Informatics to Examine the Implementation of Guideline-Directed Medical Therapy in Chronic Kidney Disease.
J Prim Care Community Health
September 2025
Division of Nephrology, Department of Medicine, National University Hospital, Singapore.
Background: Chronic kidney disease (CKD) management was largely centered around renin-angiotensin-aldosterone system inhibitors (RAASi) optimization, until recent emergence of novel therapeutics. However, slow adoption of guideline-directed therapy leaves patients vulnerable to disease progression. In 2022, a data-driven informatics approach was introduced to track real-time adherence to best practices.
View Article and Find Full Text PDFEuropean Bioanalysis Forum recommendation on embracing a context-of-use-driven scientific validation for chromatographic assays in the light of ICH M10.
Bioanalysis
September 2025
GSK, Precision Medicine Design Assurance, Stevenage, UK.
The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use M10 guideline provides a global framework for bioanalytical method validation in studies intended for regulatory submission. While its structure ensures consistency and data reliability, the guideline also acknowledges that not all studies require the same level of validation. This paper examines where full compliance is essential and where scientific judgment allows for leaner, context-driven validation, such as in early-stage development, for additional matrices, metabolites, nonstandard biological matrices or studies intended for internal decision-making.
View Article and Find Full Text PDFPsychiatric Diagnoses in Prehospital Emergency Care and Sociodemographic Characteristics of the Incident Location at the District Level.
Prehosp Disaster Med
September 2025
Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
Background: The aim of this study was to analyze the prevalence of psychiatric symptoms in prehospital emergency care and the characteristics of this patient group as well as the association with deprivation in the district, self-assessment of health status, and the frequency of emergency calls due to or accompanied by psychiatric diagnoses.
Methods: A retrospective cross-sectional study descriptively and analytically evaluated all ground-based Emergency Medical Service and rescue service incidents dispatched by the Integrated Regional Control Center (IRLS) in the period from January 1, 2021 through December 31, 2021. In addition to the clinical parameters and the demographic data of the patients, the sociodemographic characteristics of the incident location at the district level, unemployment rate, net equivalent household income, and the proportion of single-person households, as well as personal assessment of mental health and overall well-being, were included in the study.
Impact of guideline-directed medical therapy on the cardiac or non-cardiac death in acute myocardial infarction.
Korean J Intern Med
September 2025
Department of Emergency Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Background/aims: While the clinical effectiveness of guideline-directed medical therapy (GDMT) is well established in patients with acute myocardial infarction (AMI), its specific impact on cause-specific mortality remains unclear. This study aimed to investigate the impact of GDMT on both cardiac and non-cardiac mortality in AMI patients.
Methods: Data of the KAMIR-NIH, a multicenter prospective registry of AMI in Korea between 2011 and 2015, were included.
Guiding Faith Community Nursing Through Position Statement Development.
J Christ Nurs
September 2025
Professional and specialty nursing organizations (SNOs) develop position statements to offer practice guidance, amplify the views of nursing, educate consumers and decision makers, and encourage research. The Westberg Institute Research Committee, with representatives from other faith community nursing specialty organizations, has answered frequently asked practice questions by developing position statements using a rigorous process of statement development underpinned by topic exploration and synthesis of existing research and utilizing surveys to assess current practice. The processes for creating a position statement, Faith Community Nursing's Response to Inclusion, Diversity and Cultural Sensitivity, and revising Faith Community Nursing: Hands-On, Direct Care, and Specialized Care are presented.
View Article and Find Full Text PDF