Mantle cell lymphoma presenting with lethal atraumatic splenic rupture.

Autops Case Rep

University of Vermont Medical Center, Department of Pathology and Laboratory Medicine, Burlington, VT, USA.

Published: November 2021


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Article Abstract

Mantle cell lymphoma is characterized by t(11;14) with fusion and manifests with a spectrum of disease ranging from relatively indolent to aggressive. Here, we present a case of pleomorphic mantle cell lymphoma with three fusion signals that presented with lethal atraumatic splenic rupture. We discuss on the implications of variant CCND1 signal patterns as well as the epidemiology and pathophysiology of atraumatic splenic rupture.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8597805PMC
http://dx.doi.org/10.4322/acr.2021.340DOI Listing

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