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http://dx.doi.org/10.1186/s13063-021-05824-2 | DOI Listing |
IEEE J Biomed Health Inform
September 2025
Drug-target interaction (DTI) identification is of great significance in drug development in various areas, such as drug repositioning and potential drug side effects. Although a great variety of computational methods have been proposed for DTI prediction, it is still a challenge in the face of sparsely correlated drugs or targets. To address the impact of data sparsity on the model, we propose a multi-view neighborhood-enhanced graph contrastive learning approach (MneGCL), which is based on graph clustering according to the adjacency relationship in various similarity networks between drugs or targets, to fully exploit the information of drugs and targets with few corrections.
View Article and Find Full Text PDFBioresour Technol
September 2025
State Key Laboratory of Food Science and Resources, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; School of Biotechnology and Key Laboratory of Industrial Biotechnology Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, China; International Joint Laboratory on Fo
Recombinant proteins have been widely applied in the food, biomedical, and scientific fields. Prokaryotic expression systems are preferred platforms for recombinant protein production due to their rapid growth and high protein yields. Nevertheless, disparities between recombinant expression environment and native physiological conditions frequently result in protein misfolding, leading to aggregation into non-functional inclusion bodies or proteolytic degradation.
View Article and Find Full Text PDFObjective: The study examined how mobile phone dependency (MPD) is linked to adolescents' engagement in structured exercise and whether this association operates through three theoretically derived mechanisms-self-control (SC), time management (TM), and health awareness (HA). A complementary configurational analysis explored alternative combinations of these factors that lead to high or low exercise participation.
Methods: A cross-sectional survey was administered to 1,404 Chinese students in Grades 5-9 (49.
Adv Sci (Weinh)
September 2025
School of Mathematics, Shandong University, Jinan, Shandong, 250100, China.
scATAC-seq enables the detailed exploration of epigenetic variations across various cell clusters, providing complementary insights to scRNA-seq. However, its extreme sparsity and high dimensionality pose significant challenges for cell type annotation. Transfer learning can extract key features from well-annotated data to assist in annotating target data, thereby improving annotation accuracy.
View Article and Find Full Text PDFBMC Oral Health
September 2025
Physiotherapy and Orofacial Pain Working Group, Sociedad Española de Disfunción Craneomandibular y Dolor Orofacial (SEDCYDO), Madrid, 28009, Spain.
Objective: To evaluate the effectiveness of biofeedback (BF) as a potential educational treatment for temporomandibular disorders (TMD) through a systematic review and a network meta-analysis.
Methods: A systematic search was conducted across five electronic databases (PubMed, Web of Science, PEDro, Scopus, and Cochrane Library) to identify clinical trials using BF as a therapeutic intervention in patients diagnosed with TMD according to RDC/TMD or DC/TMD criteria. A frequentist fixed-effects network meta-analysis was performed with robust variance estimation to account for within-study correlations in the repeated measures.