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Populations composed of a collection of subpopulations (demes) with random migration between them are quite common occurrences. The emergence and sustenance of cooperation in such a population is a highly researched topic in the evolutionary game theory. If the individuals in every deme are considered to be either cooperators or defectors, the migration dilemma can be envisaged: The cooperators would not want to migrate to a defector-rich deme as they fear of facing exploitation; but without migration, cooperation cannot be established throughout the network of demes. With a view to studying the aforementioned scenario, in this paper, we set up a theoretical model consisting of a coupled map lattice of replicator maps based on two-player-two-strategy games. The replicator map considered is capable of showing a variety of evolutionary outcomes, like convergent (fixed point) outcomes and nonconvergent (periodic and chaotic) outcomes. Furthermore, this coupled network of the replicator maps undergoes the phenomenon of amplitude death leading to nonoscillatory stable synchronized states. We specifically explore the effect of (i) the nature of coupling that models migration between the maps, (ii) the heterogenous demes (in the sense that not all the demes have the same game being played by the individuals), (iii) the degree of the network, and (iv) the cost associated with the migration. In the course of investigation, we are intrigued by the effectiveness of the random migration in sustaining a uniform cooperator fraction across a population irrespective of the details of the replicator dynamics and the interaction among the demes.
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http://dx.doi.org/10.1103/PhysRevE.104.044304 | DOI Listing |
Diabetes Obes Metab
September 2025
Canada Excellence Research Chair in Genomic Medicine, McGill University, Montréal, Québec, Canada.
Aims: To evaluate relationships of cardiovascular and kidney outcomes with glycemic or bodyweight reductions in randomised placebo-controlled trials of glucagon-like peptide-1 receptor agonists (GLP-1RAs), incorporating data from FLOW and SOUL trials.
Materials And Methods: PubMed and EMBASE were searched up to 22 August 2025 for placebo-controlled randomized trials of oral or bolus-type, subcutaneous GLP-1RAs reporting major adverse cardiovascular events (MACE; a composite of cardiovascular death, myocardial infarction, and stroke) in adults with type 2 diabetes. The primary outcome was MACE; secondary outcomes included heart failure (HF) and kidney outcomes.
Biochem Biophys Res Commun
August 2025
Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilove st., 119991, Moscow, Russia.
Over the past decade, increasing attention has been directed toward the development and evaluation of novel anticancer agents based on nanotechnology. Nanoparticles (NPs) have emerged both as standalone anticancer agents and as carriers for targeted drug delivery. Various types of nanoparticles are being investigated in combinatorial cancer therapies alongside radiotherapy or immunomodulatory agents, with the aim of reducing drug resistance and enhancing apoptotic responses within tumors.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Biology, University of British Columbia - Okanagan Campus, Kelowna, BC, Canada.
Mechanical strain plays a significant role in lung pathophysiology. Current two-dimensional (2D) models fail to capture the lung's dynamic mechanical environment. We developed mechanically strained 2D and more complex three-dimensional (3D) alveolar epithelial-fibroblast co-cultures and organoids using the Flexcell cell stretching bioreactor.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of General Surgery, The Second Hospital of Shandong University, Jinan, Shandong, China.
Background: Gallbladder and biliary tract diseases (GBDT) is a common digestive disorder; however, comprehensive epidemiological data from China are still limited.
Methods: This study utilized the Global Burden of Disease Study 2021 database to examine the burden of GBDT from 1990 to 2021. The key metrics analyzed included age-standardized incidence rate (ASIR), prevalence rate (ASPR), rate of mortality (ASMR), and age-standardized disability-adjusted life years rate (ASDR).
BMJ Open
August 2025
Department of Rehabilitation Meidicine, Southeast University Zhongda Hospital, Nanjing, Jiangsu, China
Objective: This study aimed to investigate the characteristics of the blink reflex and its prognostic value for consciousness improvement in patients with prolonged disorders of consciousness (DOC).
Design: Prospective case-control study.
Setting: This study was conducted in a local hospital between March 2022 and March 2023.